Antioxidant properties of a cathiasine-based pharmaceutical composition studied on a model of the drug-induced liver impairment
The paper studies the antioxidant potential of a pharmaceutical composition (PhC) based on cathiazine
(a camphoric acid derivative with a sperm-stimulating action) and succinic acid within the paracetamol-induced
hepatitis in rats. We determined the content of the lipids peroxidation (LPO) products, content of the stable nitric
oxide metabolites and activity of the antioxidant system in the liver, serum or whole blood.
Authors found that, when administered orally to rats with hepatitis, the PhC stimulated a glutathione unit
of the antioxidant system as well as restored (up to a control level) the intensity of LPO processes, content of the
nitrite and nitrate anions in the liver and whole organism, in such a way ensuring the functional state of the
liver normalization. The obtained results testify good prospects of using the PhC with cathiazine + succinic acid
as a hepatic protector with the pronounced antioxidant properties in correcting the general liver pathology and
its combination with the impaired spermatogenesis.
K e y w o r d s : cathiazine-based pharmaceutical composition, paracetamol-induced hepatitis, anti-oxidant
system, nitrogen oxide, lipids peroxidation.