Molekular-genetic markers of the follicular cancer of the thyroid gland development
The frequencies of P12A and H449H mutations in the 2 and 6 exons of the PPARγ gene in patients with thyroid neoplasia were obtained. 128 thyroid tissue samples (29-follicular adenoma, 48-follicular cancer, 51-papillary cancer) were investigated for the presence of mutations. A differentiated contribution of the investigated mutations to the manifestation of follicular carcinoma is shown. The mutations P12A and H449H in the 2 and 6 exons of the PPARγ gene are associated with the follicular structure of the neoplasia, but do not affect the malignant or benign variant of their development. The presented results are of direct practical importance. Since the P12A mutation in the 2 exon of the PPARγ gene is specific to the follicular variant of the thyroid neoplasia, its determination may be a useful additional method for differential diagnosis of nodal tumors of the thyroid.
K ey wor d s : thyroid gland, follicular and papillary neoplasias, thyroid cancer, P12A and H449H mutations in the 2 and 6 exons of the PPARγ gen
Sazonov M.Y., S. A. Shtandel, Karachentsev Y., Khaziev V.V., Dubovik V.M., Gopkalova I.V.