EVALUATION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN PATIENTS WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS

Authors

  • Bilchenko O. V. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Lipakova K. Y. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Rudenko T. A. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
  • Vysotska О. V. National Aerospace University – «Kharkiv Aviation Institute»; Kharkiv, Ukraine
  • A. P. Porvan National Aerospace University – «Kharkiv Aviation Institute»; Kharkiv, Ukraine
  • Karami Saliba D. Y. Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2020.1.01

Keywords:

coronary heart disease, type 2 diabetes mellitus, chronic heart failure, prognosis of the course, preserved ejection fraction

Abstract

The aim is to develop a method for predicting the course of heart failure (HF) in patients with coronary heart disease (CHD) in combination with type 2 diabetes mellitus (DM). The study included 100 men aged 50 to 67 years with CHD in combination with type 2 DM. Patients were divided into two groups depending on the course of HF: I (n = 66) — with a favorable course, II (n = 34) — with an unfavorable course (decreased LV EF, patients with impaired diastolic function, and those who died during the year of observation). Analysis of cardiovascular anamnesis and indicators of carbohydrate and lipid metabolism were conducted; a transthoracic echocardiography was performed; endothelium-dependent dilation of the brachial artery (EDD) was studied. The Mann-Whitney U-test was used to determine the differences between independent samples, and the logistic regression method was used for prognosis. On the basis of the conducted research, a method for determining the prognosis of HF during a year in patients with coronary heart disease in combination with type 2 DM is proposed, by which, through additional research and determination of clinical and laboratory features with subsequent calculation, the prediction is achieved. For prognosis and subsequent calculation the formula using coefficients for prognostic factors, it is necessary to study EDD, arterial blood pressure with a calculation of pulse pressure, determine serum insulin with the calculation of the HOMA index, and use the regression equation with a high level of sensitivity and specificity to determine the probability of an adverse course of HF in patients with preserved ejection fraction.

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Published

2020-03-03

How to Cite

Bilchenko, O. V., Lipakova, K. Y., Rudenko, T. A., Vysotska О. V., Porvan, A. P., & Karami Saliba, D. Y. (2020). EVALUATION OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN PATIENTS WITH CORONARY HEART DISEASE AND TYPE 2 DIABETES MELLITUS. Problems of Endocrine Pathology, 71(1), 7-13. https://doi.org/10.21856/j-PEP.2020.1.01

Issue

Section

CLINICAL ENDOCRINOLOGY