@article{Gorshunska_Karachentsev_Kravchun_Jansen_Atramentova_Gladkih_Krasova_Leshchenko_Tyzhnenko_Opaleiko_Pochernyaev_Роltorak_2013, title={GENETIC VARIANTS OF ADIPONECTIN AND THERAPEUTIC EFFICIENCY OF OMEGA-3 POLYUNSATURATED FATTY ACIDS IN PATIENTS TYPE 2 DIABETES MELLITUS}, volume={43}, url={https://jpep.endocrinology.org.ua/index.php/1/article/view/553}, DOI={10.21856/j-PEP.2013.1.01}, abstractNote={<p>In 61 type 2 diabetic patients it was defined single nucleotide polymorphism +276 G &gt; T (rs1501299 ) in adiponectin gene and atherogenic potential dynamics (hormonal and metabolic parameters of insulin resistance, a pro-inflammatory state, oxidative status, adipokines) after daily administration for 12 weeks of omega-3 polyunsaturated fatty acids (Omacor) with the constant pattern of antidiabetic therapy. After the treatment, in all the surveyed it was revealed reduction of insulin resistance, while a significant increase in the levels of total adiponectin, total erythrocyte glutathione, as well as reduced levels of circulating insulin and osteoprotegerin were observed only in carriers of GG-genotype. These results suggest that genetic variations in the adiponectin gene can affect the therapeutic efficacy of omega-3 fatty acids, namely, to reduce the pattern of cardiovascular risk factors in type 2 diabetic patients in a Ukrainian population.</p>}, number={1}, journal={Problems of Endocrine Pathology}, author={Gorshunska, Maryana and Karachentsev, Yuri and Kravchun, Nona and Jansen, E. and Atramentova, L. O. and Gladkih, Olexander and Krasova, Nataliya and Leshchenko, Zhanna and Tyzhnenko, T. V. and Opaleiko, Y. A. and Pochernyaev, A. K. and Роltorak V. V.}, year={2013}, month={Mar.}, pages={5-14} }