@article{Bondarenko_Goncharova_Minukhin_Skornyakov_2021, title={Vitamin D, Testosterone, and Thyroid Status in Young Men at Different Seasons}, volume={77}, url={https://jpep.endocrinology.org.ua/index.php/1/article/view/617}, DOI={10.21856/j-PEP.2021.3.04}, abstractNote={<p>There are evidences that seasonal fluctuations in vitamin D levels coincide with annual rhythms of testosterone levels, and hypothyroidism may be a predictor of hypoandrogenism.</p> <p>The aim of the study was to establish the levels of vitamin D (vit. D), testosterone (T), thyroid stimulating hormone (TSH) and free thyroxine (T<sub>4f</sub>) in young people with pathospermia and normospermia in the spring-summer and autumn-winter periods.</p> <p>Materials and methods. The data of 58 men aged 23-44 years, who are in a sterile marriage, were analyzed: 24 were examined in the spring-summer period, 34 - in the autumn-winter period. BMI, levels of T, TSH, T<sub>4f</sub>andvit. Dwere investigated.</p> <p>Results. In the general group of men, the frequency of D - hypovitaminosis was higher in those examined in the autumn-winter period. Vit D levels were significantly lower with pathospermia than with normospermia. BMI did not significantly affect the level of vit.D in the blood.A direct correlation between vit.&nbsp;D and T in men with patho- and normospermiahas not been established, although such a correlation took place in the general group of the surveyed.</p> <p>The average TSH values ​​in the group examined in the spring-summer period did not significantly differ in the group with patho- and normospermia, and in those examined in the autumn-winter period, against the background of pathospermia, there was a decrease in T<sub>4f</sub> values ​​and an increase in TSH. 13.6% of this subgroup had laboratory signs of subclinical hypothyroidism.</p> <p>Conclusions:</p> <ol> <li class="show">In men of the general group, without taking into account the state of the spermatogenic function of the testicles, examined in the autumn-winter period, there is a significant increase in the frequency of D-hypovitaminosis compared with a similar group of men in whom the level of vitamin D blood was determined in the spring-summer period.</li> <li class="show">Regardless of the examination period, patients with pathospermia show a decrease in the average levels of vitamin D and testosterone compared to men with normal semen parameters.</li> <li class="show">The frequency of vitamin D deficiency in patients with pathospermia significantly increases in the autumn-winter period.</li> </ol> <p>Disorders of spermatogenesis in men can be associated with the hypofunctional state of the thyroid gland against the background of the existing deficiency of vitamin D in the autumn-winter period.</p>}, number={3}, journal={Problems of Endocrine Pathology}, author={Bondarenko, Vladimir and Goncharova, Olga and Minukhin, Andriy and Skornyakov, Evgeniy}, year={2021}, month={Sep.} }