@article{Серік_Мавричева_Ченчик_2021, title={MONOCYTE CHEMOATTRACTANT PROTEIN-1 LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CORONARY ARTERY DISEASE }, volume={78}, url={https://jpep.endocrinology.org.ua/index.php/1/article/view/926}, DOI={10.21856/j-PEP.2021.4.08}, abstractNote={<p><strong>Background. </strong>Mechanisms of atherosclerotic cardiovascular diseases in patients with diabetes mellitus have not been fully clarified. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory chemokine which plays a key role in the pathophysiology of both atherosclerosis and diabetes.</p> <p><strong>The aim</strong> of the study was to investigate MCP-1 levels in patients with coronary artery disease (CAD) with type 2 diabetes mellitus (T2DM) depending on previous history of myocardial infarction and percutaneous coronary intervention (PCI).</p> <p><strong>Materials and Methods.</strong> Serum MCP-1 levels were measured in 31 patients with stable CAD with T2DM, 26 non-DM patients with CAD, and 15 control group persons.</p> <p><strong>Results. </strong>MCP-1 level in patients with CAD with T2DM was higher than in the control group (p=0,0007) and non-DM patients with CAD (р=0,039). The elevation of MCP-1 level in non-DM patients with CAD was insignificant. There were no correlations of MCP-1 levels with glucometabolic and lipid indices in any groups. MCP-1 levels did not differ significantly in CAD patients with and without a history of previous myocardial infarction both in non-DM patients and in patients with T2DM. CAD patients with T2DM with a history of PCI more than 1 year previously have higher MCP-1 levels than CAD patients with T2DM without a history of PCI (p=0,038). In non-DM patients with CAD with the same history of PCI MCP-1 decreased compared to non-DM patients without previous PCI (p=0,030).</p> <p><strong>Conclusions. </strong>In patients with CAD with T2DM MCP-1 level increased in comparison with the controls and CAD patients without T2DM. CAD patients with T2DM with a history of PCI have highest MCP-1 level.</p>}, number={4}, journal={Problems of Endocrine Pathology}, author={Серік, Сергій and Мавричева, Наталія and Ченчик, Тетяна}, year={2021}, month={Dec.}, pages={57-64} }