TY - JOUR AU - Arkhypkina, T. L. AU - Karachentsev, Y. I. AU - Lyubimova, L.P. AU - Abdullaev, R.Ya. AU - Bondarenko, V. A. PY - 2021/06/24 Y2 - 2024/03/29 TI - THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (literature review and own result ) JF - Problems of Endocrine Pathology JA - PEP VL - 58 IS - 4 SE - DO - 10.21856/j-PEP.2016.4.12 UR - https://jpep.endocrinology.org.ua/index.php/1/article/view/429 SP - 91-104 AB - <p>The increase of VEGF which is not dependent on the levels of LH, T and E2 was found at 80 patients with PCOS. The existence of a positive correlation between the VEGF and the ovarian volume, the number of antral follicles and the blood flow velocity it was proved. The existence of the connection between the VEGF and the ET-1, the HC at the early stages of the disease that indicates the presence of endothelial dysfunction has been established. The presence of interconnection between the VEGF and the AMH at more severe disturbances of follicular structures of ovarian was established. It is suggested that the VEGF, as the AMH indicates the severity of the disease. The data allow to consider the VEGF as one of the key pathophysiological factors that contribute to the development of PCOS, and with such parameters as the volume of the ovaries, the number of antral follicles, blood flow in the arteries of the ovaries and the increase of the level of AMH — as a marker of PCOS.</p> ER -