TY - JOUR AU - Mykytyuk, Myroslava PY - 2012/10/10 Y2 - 2024/03/28 TI - ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY JF - Problems of Endocrine Pathology JA - PEP VL - 41 IS - 3 SE - DO - 10.21856/j-PEP.2012.3.03 UR - https://jpep.endocrinology.org.ua/index.php/1/article/view/658 SP - 21-27 AB - <p>Investigation of the carbohydrate methabolism was done in 97 patients with active acromegaly<br>including 21 de novo acromegaly patients. Effects of growth hormone, insulin-like growth factor-1 and<br>prolactin on sensitivity to insulin and β-sell function were determined due to analysis of associations<br>of those hormones with insulin and HOMA indices. The role of permanent hypersomatotropinemy in<br>the pathogenesis of insulin-resistance and compensatory hyperinsulinemy in patients with acromegaly<br>was discussed.</p> ER -