TY - JOUR AU - Попов, Микола AU - Лядова, Тетяна AU - Оленич, Віра AU - Огнівенко, Олена AU - Савво, Олексій AU - Сухоносова, Ольга PY - 2022/03/15 Y2 - 2024/03/29 TI - CHEMICAL CHARACTERISTICS OF PERIPHERAL BLOOD GRANULOCYTE BIOMEMBRANES IN FREQUENTLY ILL CHILDREN WITH AUTONOMIC DYSFUNCTION SYNDROME AND OVERWEIGHT JF - Problems of Endocrine Pathology JA - PEP VL - 79 IS - 1 SE - DO - 10.21856/j-PEP.2022.1.16 UR - https://jpep.endocrinology.org.ua/index.php/1/article/view/971 SP - 118-124 AB - <p>Frequently ill children (FID) constitute a special group of patients that requires close attention from medical specialists. This is especially true for children born prematurely, with perinatal lesions of the central nervous system (CNS), who later developed a syndrome of autonomic dysfunctions with overweight and have lower immunoreactivity compared to healthy peers.</p><p><strong>Purpose </strong>of the work is to study the state of biochemical parameters of immunocompetent cells (phospholipid (PL) composition of granulocyte membranes) in FIC with autonomic dysfunction syndrome with overweight, who were born prematurely with perinatal CNS damage.</p><p><strong>Materials and methods.</strong> We examined 68 children aged 6-7 years from the FIC group, who were divided as follows: Group 1 – 36 children with autonomic dysfunction syndrome (ADS) with overweight, who were born prematurely with perinatal hypoxic-ischemic CNS lesion; Group 2 – 32 children with ADS and normal weight. The control group consisted of 30 healthy children. The biochemical research program consisted in the study of the PL composition of granulocyte membranes.</p><p><strong>Results.</strong> The study of the PL composition of the granulocyte membranes in the study groups established probable differences in comparison with the indicators of the control group. The obtained data indicate an increase in the content of unsaturated fatty acids and violation of the ratio saturated / unsaturated fatty acids in blood cell biomembranes in FID. This was also accompanied by increased oxidation of membrane lipids, as evidenced by high levels of lysophosphatidylcholines. In particular, changes in granulocyte biomembranes were more pronounced in the group of children with ADS and overweight compared to children with normal weight.</p><p><strong>Conclusions.</strong> Frequently ill children born prematurely with perinatal hypoxic-ischemic damage to the central nervous system, both normal and overweight, changes in immunocompetent cells are characterized by certain features, which are manifested by increased polarity of the lipid component and a decrease in the relative content of neutral lipids in biomembranes. These disorders cause changes in protein-lipid interactions and changes in microviscosity, and structural and functional properties of biomembranes. The revealed changes in the biochemical characteristics of the membranes occur to a greater extent under conditions of overweight. This suggests that overweight children in addition to metabolic have certain features of neurological and immune status, which are realized in the conditions of altered individual reactions on the background of metabolic disorders. This emphasizes the need for a multidisciplinary approach to the problem of overweight in children to help reduce body weight, and also improve the cardiovascular, nervous and immune systems.</p> ER -