THE IMPACT OF ENDOGENOUS AND EXOGENOUS ESTROGENS ON METABOLIC DISTURBANCES IN FEMALE RATS WITH TYPE 2 DIABETES
DOI:
https://doi.org/10.21856/j-PEP.2016.1.06Keywords:
type 2 diabetes, estrogen deficiency, estradiol derivativeAbstract
It was investigated the impact of endogenous and exogenous estrogens on metabolic disturbances in female rats with type 2 diabetes. It was established that hypoestrogenic state increases insulin resistance, but doesn’t affect basal hyperglycemia, dyslipidemia and visceral obesity in diabetic female rats. Administration of compound PE0607 with selective estrogen-like activity as well as 17β-estradiol doesn’t influence hyperglycemia and insulin sensitivity, but suppresses dyslipidemia development. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for attenuation of cardiometabolic risk in type 2 diabetic women.
References
IDF: Diabetes Atlas, 6th ed., Brussels, 2015: 144 p.
Huxley R, Barzi F, Woodward M. BMJ 2006; 332(7533):73-78.
Barrett-Connor E. Glob Heart 2013; 8(2), available at: http://www.ncbi.nlm.nih.gov.
Ferrara A, Quesenberry CP, Karter AJ, et al. Circulation 2003; 107(1):43-48.
Newton KM, Lacroix AZ, Heckbert SR, et al. Diabetes Care 2003; 26(10):2810-2816.
Gorbenko NI, Taran KV, Jaremenko FG. Liky -ljudyni: materialy 27-i’ nauk.-prakt. konf., Harkiv, 2010:32-33.
Taran KV, Gorbenko NI, Ivanova OV, Jaremenko FG. Probl Endokryn Patologii’ 2011; 1:32-39.
Gorbenko NI, Taran KV, Ivanova OV, et al. Materialy VII nac. z’i’zdu farmacevtiv Ukrai’ny, Harkiv, 2010: 32.
Patent 96493. Sposib modeljuvannja cukrovogo diabetu 2 typu za umov deficytu estrogeniv, 2015: 4 p.
Mukhina TV, et al. Zh Vyssh Nerv Deiat Im 2003; 53(2):208-214.
Baker J, Metcalf P, Scragg R, Johnson R. Clin Chem 1991; 37(4):552-556.
Akinmokun A, et al. Diabet Med 1992; 9(4):432-437.
Prohorova MI, Tupikova ZN. Bol’shoj praktikum po uglevodnomu i lipidnomu obmenu, Leningrad, 1965: 218 p.
Dumcombe WC. Biochem J 1963; 188(1):7-10.
Fletcher MJ. Clin Chim Acta 1968; 22(3):393-397.
Glans S. Mediko-biologicheskaja statistika, Moskva, 1998: 459 p.
Gorbenko NI, Oksenenko SV, Borikov OJu, et al. Prakt Medycyna 2008; 14(2):118-126.
Villeneuve LM, Natarajan R. Am J Physiol Renal Physiol 2010; 299(1):F14-F25.
Duckles SP, Krause DN, Stirone C, Procaccio V. Molec Interv 2006; 6(1):26-35.
Nandi A, Poretsky L. Endocrinol Metab Clin North Amer 2013; 42(4):915-946.