THE IMPACT OF ENDOGENOUS AND EXOGENOUS ESTROGENS ON METABOLIC DISTURBANCES IN FEMALE RATS WITH TYPE 2 DIABETES

Authors

DOI:

https://doi.org/10.21856/j-PEP.2016.1.06

Keywords:

type 2 diabetes, estrogen deficiency, estradiol derivative

Abstract

It was investigated the impact of endogenous and exogenous estrogens on metabolic disturbances in female rats with type 2 diabetes. It was established that hypoestrogenic state increases insulin resistance, but doesn’t affect basal hyperglycemia, dyslipidemia and visceral obesity in diabetic female rats. Administration of compound PE0607 with selective estrogen-like activity as well as 17β-estradiol doesn’t influence hyperglycemia and insulin sensitivity, but suppresses dyslipidemia development. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for attenuation of cardiometabolic risk in type 2 diabetic women.

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Published

2016-03-02

How to Cite

Kiprich, T., Gorbenko, N., Borikov, O., & Ivanova, O. (2016). THE IMPACT OF ENDOGENOUS AND EXOGENOUS ESTROGENS ON METABOLIC DISTURBANCES IN FEMALE RATS WITH TYPE 2 DIABETES. Problems of Endocrine Pathology, 55(1), 41-47. https://doi.org/10.21856/j-PEP.2016.1.06

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