AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU

Authors

  • Dielievska V. Yu. 1Kharkiv National Medical University, department of internal medicine № 2 and clinical immunology and allergology, Kharkiv, Ukraine
  • Dunaeva I. P. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2016.1.03

Keywords:

autoantibodies against type IV collagen, type 2 diabetes mellitus, chronic heart failure, chronic obstructive pulmonary disease, arterial hypertension

Abstract

We examined whether autoantibodies against type IV collagen are associated with heart failure progression in arterial hypertension combined with chronic obstructive pulmonary disease with and without type 2 diabetes mellitus. Both patients with chronic heart failure in essential hypertension and chronic obstructive pulmonary disease and patients with concomitant type 2 diabetes mellitus showed higher levels of plasma type IV collagen autoantibodies in comparison to healthy controls. Type IV collagen antibodies correlated with dilation of the left ventricle and reduction of its contractility. Elevation of plasma type IV collagen autoantibodies is associated with progression of chronic heart failure in arterial hypertension combined and chronic obstructive pulmonary with and without type 2 diabetes mellitus.

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Published

2021-08-18

How to Cite

Dielievska, V. Y. ., & Dunaeva, I. P. (2021). AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU. Problems of Endocrine Pathology, 55(1), 23-28. https://doi.org/10.21856/j-PEP.2016.1.03

Issue

Section

CLINICAL ENDOCRINOLOGY

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