AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU
DOI:
https://doi.org/10.21856/j-PEP.2016.1.03Keywords:
autoantibodies against type IV collagen, type 2 diabetes mellitus, chronic heart failure, chronic obstructive pulmonary disease, arterial hypertensionAbstract
We examined whether autoantibodies against type IV collagen are associated with heart failure progression in arterial hypertension combined with chronic obstructive pulmonary disease with and without type 2 diabetes mellitus. Both patients with chronic heart failure in essential hypertension and chronic obstructive pulmonary disease and patients with concomitant type 2 diabetes mellitus showed higher levels of plasma type IV collagen autoantibodies in comparison to healthy controls. Type IV collagen antibodies correlated with dilation of the left ventricle and reduction of its contractility. Elevation of plasma type IV collagen autoantibodies is associated with progression of chronic heart failure in arterial hypertension combined and chronic obstructive pulmonary with and without type 2 diabetes mellitus.
References
Loehr LR, Rosamond WD, Chang PP, et al. Am J Cardiol 2008; 101:1016-1022.
Redfield MM, et al. JAMA 2003; 289:194-202.
Jushkov PV, Opalenov KV. Saharnyj Diabet 2001;12:53-56.
Nikolov A, Nicoloff G, Tsinlikov I, Tsilnikova I. J IMAB 2012; 18(3):315-322.
Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Am J Respir Crit Care Med 2008; 177(2):156-163.
Karayama M, Inui N, Suda T, et al. Chest 2010;138:1303–1308.
Kirkham PA, Caramori G, Casolari P, et al. Am J Respir Crit Care Med 2011; 184:796-802.
Toyoshima M, Chida K, Suda T, Sato M. Am J Respir Crit Care Med 2011; 184:1212–1213.
Lee SH, Goswami S, Grudo A, et al. Nat Med 2007;13:567–569.
Rinaldi M, Lehouck A, Heulens N, et al. Thorax 2012; 67(8):694-700.
Kranenburg AR, Willems-Widyastuti A, Moori WJ, et al. Am J Clin Pathol 2006; 126:725-735.
Daffa NI, Tighe PJ, Corne JM, et al. Clin Exp Immunol 2014. — doi: http://doi.org/10.1111/cei.12565.
Núñez B, Sauleda J, Antó JM, et al. Am J Respir Crit Care Med 2011; 183:1025-1031.
Tandon R, Sharma M, Chandrashekhar Y, et al. Nat Rev Cardiol 2013; 10(3):171–177.
Dinkla K, Rohde M, Jansen WT, et al. J Clin Invest 2003; 111(12):1905-1912.
Matache C, Stefanescu M, Ivanov D, et al. Roum Arch Microbiol Immunol 1992; 51(4):197-203.
Nicoloff G, Baydanoff S, Petrova C, Christova P. A longitudinal study Vascul Pharmacol 2002;38(3):143-147.
Global initiative for Chronic Obstructive Lung Disease, available at: www.goldcopd.com/