ASSESSMENT OF INSULIN PRODUCTED PANCREATIC FUNCTION IN PATIENTS WITH DIABETES MELLITUS WITH DIFFERENT DEGREES OF INSULIN DEFICIENCY

Authors

  • Khyzhnyak O. O. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Tykhonova T. M. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Barabash N.E. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2016.4.06

Keywords:

type 1 and 2 diabetes mellitus, slowly progressive autoimmune diabetes of adults, C-peptide, an absolute insulin deficiency

Abstract

The study involved 162 people, including 61 patients with type 1 diabetes mellitus (DM), 70 patients with slowly progressive autoimmune diabetes of adults and 31 patients with type 2 diabetes with the development of insulin dependence after more than 10 years since the disease onset. Based on a comparative analysis of fasting C-peptide levels in patients of observation groups the different degree of insulin secretion reduction was set. Thus in patients with type 1 diabetes mellitus severity of absolute insulin deficiency is not a determining factor of the variant of the disease (relatively stable or labile). In general, the definition of C-peptide in patients with diabetes is a reliable criterion by which we can judge the functional activity of β-cells, even in the appointment of insulin. In doubtful cases it is advisable to carry out the research of C-peptide in the dynamics of observation.

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Published

2021-06-24

How to Cite

Khyzhnyak, O. O., Tykhonova, T. M., & Barabash, N. E. (2021). ASSESSMENT OF INSULIN PRODUCTED PANCREATIC FUNCTION IN PATIENTS WITH DIABETES MELLITUS WITH DIFFERENT DEGREES OF INSULIN DEFICIENCY. Problems of Endocrine Pathology, 58(4), 42-48. https://doi.org/10.21856/j-PEP.2016.4.06

Issue

Section

CLINICAL ENDOCRINOLOGY

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