THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (literature review and own result )

Authors

  • Arkhypkina T. L. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Karachentsev Y. I. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Lyubimova L.P. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv
  • Abdullaev R.Ya. Kharkiv Postgraduate Medical Academy, Kharkiv
  • Bondarenko V. A. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2016.4.12

Keywords:

polycystic ovary syndrome, vascular endothelial growth factor, endothelial dysfunction, doppler

Abstract

The increase of VEGF which is not dependent on the levels of LH, T and E2 was found at 80 patients with PCOS. The existence of a positive correlation between the VEGF and the ovarian volume, the number of antral follicles and the blood flow velocity it was proved. The existence of the connection between the VEGF and the ET-1, the HC at the early stages of the disease that indicates the presence of endothelial dysfunction has been established. The presence of interconnection between the VEGF and the AMH at more severe disturbances of follicular structures of ovarian was established. It is suggested that the VEGF, as the AMH indicates the severity of the disease. The data allow to consider the VEGF as one of the key pathophysiological factors that contribute to the development of PCOS, and with such parameters as the volume of the ovaries, the number of antral follicles, blood flow in the arteries of the ovaries and the increase of the level of AMH — as a marker of PCOS.

References

Juz’ko OM, Juz’ko TA, Rudenko NG. Neonatologija, Hirurgija ta Perynatal’na Medycyna 2012; 11(4):26-30.

Avramenko NV, Barkovskij DE. Zaporozh Med Zhurn 2010; 12(3):71-72.

Podzolkova NM, Koloda JuA. Farmateka 2016; 3:8-14.

Gariano RF, Gardner TW. Nature 2005; 438:960-966. doi: http://dx.doi.org/10.1038/nature04482

Gamazkov OA. Priroda 2000; 5:38-46.

Malaja LT, Korzh AN, Balkovaja LB. Jendotelial’-naja disfunkcija pri patologii serdechno-sosudistoj sistemy, Har’kov, 2000: 432 p.

Madeddu P. Experim Physiol 2004; 90(3):315-326. doi: http://dx.doi.org/10.1113/expphysiol.2004.028571

Potente M, Gerhardt H, Carmeliet P. Cell 2011; 146(6):873-887. doi: http://dx.doi.org/10.1016/j.cell.2011.08.039

Spryndzhuk MV. Morfologija 2010; 4(3):4-135.

Lam P, Haines C. Fertil Steril 2005; 84(6):1775-1778. doi: http://dx.doi.org/10.1016/j.fertnstert.2005.05.059

Makinen K. Acta Chir Belg 2003; 103:470-474. doi: http://dx.doi.org/10.1080/00015458.2003.11679469

Burlev V, AZajdieva ZS, Il’jasova NA. Problemy Reprodukcii 2008; 3:18-22.

Muller K, Ellenberger C, Schoon C. Res Veterinary Sci 2009; 87(3):421-431. doi: http://dx.doi.org/10.1016/j.rvsc.2009.04.011

Zhang Z, Luo Q, Cheng Y, Wang Z. J Veterinary Med Animal Health 2012; 4(8):97-104.

Shibuya M. J Biochem Mol Biol 2006; 39(5):469-478. doi: http://dx.doi.org/10.5483/BMBRep.2006.39.5.469

Arutjunjan IV, Kananyhina EJu, Makarov AV. Kletochnaja Transplantologija i Tkanevaja Inzhenerija2013; 8(1):12-18.

Suhih GT, Shurshalina AV. Hronicheskij jendometrit: rukovodstvo, Moskva,2013: 64 p.

Gavrilenko TI, Ryzhkova NA, Parhomenko AN. Ukr Kardiol Zhurn 2011; 4:87-95.

Zaharova NB, Durnov DA, Mihajlov VJu, et al. Fundamental’nye Issledovanija 2011; 11:215-220.

Stannard AK, Khurana R, Evans IM, et al. Arterioscler Thromb Vasc Biol 2007; 27:494-502. doi: http://dx.doi.org/10.1161/01.ATV.0000255309.38699.6c

Robinson R, Woad KJ, Hammond A, et al. Reproduction 2009; 138:869-881. doi: http://dx.doi.org/10.1530/REP-09-0283

Kaczmarek MM, Schams D, Ziecik AJ. Reprod Biol 2005; 5(2):111-136.

Tepljashina EA, Pozhilenkova EA, Ekimova MV, Salmina AB. Ros Vestn Akushera-ginekologa2011; 3:5-9.

Bozhenko OJu. Mezhdunar Zhurn Pediatrii, Akusherstva i Ginekologii 2013; 3(2):88-94.

Strizhakov AN, Pirogova MI, Shahlamova MN, et al. Voprosy Ginekologii, Akusherstva i Perinatologii 2014; 13(5):40-47.

Douglas NC, Nakhuda GS, Sauer MV, Zimmermann RC. J Fertil Reprod 2005; 13(4):7-15.

Artini RG, Monti M, Fasciani A, et al. Eur J Obstet Gynecol Reprod Biol2002; l01(2):169-174.

Lam PM, Haines C. Fertil Steril 2005; 84(6):1775-1778. doi: http://dx.doi.org/10.1016/j.fertnstert.2005.05.059

Bojarskij KJu, Gajdukov SN. Problemy Reprodukcii 2010; 5:13-23.

Sweiki D, Itin A, Neufeld J, et al. J Clin Invest 1993; 91:2235-2243. doi: http://dx.doi.org/10.1172/JCI116450

Driesche S, Myers M, Gay E, et al. Mol Hum Reprod 2008; 14(8):455-464. doi: http://dx.doi.org/10.1093/molehr/gan040

Schams D, Kosmann M, Berisha B, et al. Exp Clin Endocrinol Diab 2001; 109(3):155-162. doi: http://dx.doi.org/10.1055/s-2001-14839

Berisha B, Steffl M, Welter H, et al. Reprod Fertil Develop 2008; 20(2):258-268. doi: http://dx.doi.org/10.1071/RD07125

Hannan NJ, Paiva P, Meehan KL, et al. Endcrinology 2011; 152(12):4948-4956. doi: http://dx.doi.org/10.1210/en.2011-1248

Binder NK, Evans J, Gardner DK, et al. Hum Reprod Embryol2014; 29(10):2278-2286. doi: http://dx.doi.org/10.1093/humrep/deu211

Kudsy M, Alhalabi M, Al-Quobaili F. Middle East Fertil Soc J 2016; 21(1):52-56. doi: http://dx.doi.org/10.1016/j.mefs.2015.11.001

Artini PG, Monti M, Matteucci C, et al. Gynecol Endocrinol 2006; 22(8):465-470. doi: http://dx.doi.org/10.1080/09513590600906607

Qiao J, Feng HL. Hum Reprod Updata 2011; 17(1):17-33. doi: http://dx.doi.org/10.1093/humupd/dmq032

Agrawal R, Jacobs H, Payne N, Conway G. Fertil Steril 2011; 78(6):1164-1169. doi: http://dx.doi.org/10.1016/S0015-0282(02)04242-5

Ferrara N. EXS 2005; 94:209-231. doi: http://dx.doi.org/10.1007/3-7643-7311-3_15

Lee EJ, Oh B, Lee JY, et al. Fertil Steril 2008; 89(6):1751-1759. doi: http://dx.doi.org/10.1016/j.fertnstert.2007.06.049

Peitsidis P, Agrawal R. Reprod Bio Med 2010; 20(4):444-452.

Samy N, Afify M, Hassan A, et al. J Toxicol Pharmacol Res 2010; 6(4):123-127.

Azziz R, Carmini E, Dewailly D, et al. Guideline 2006; 9(11):4237-4245.

Khaodhiar L, Mc Cowen KC, Blackburn GL. Clin Cornerstone 1999; 2(1):17-31. doi: http://dx.doi.org/10.1016/S1098-3597(99)90002-9

Dedov II. Sindrom polikistoznyh jaichnikov: rukovodstvo dlja vrachej, Moskva, 2007: 368 p.

El Behery MM, Diab AE, Mowafy H, et al. Intern J Gynecol Obstet 2011; 112(2):119-121.

Meldrum D. Fertil Steril 2002; 78(6):1170-1171. doi: http://dx.doi.org/10.1016/S0015-0282(02)04244-9

Makarishhev AJa. Klinicheskoe znachenie sosudistogo jendotelial’nogo faktora rosta pri sindrome polikistoznyh jaichnikov, Moskva, 2007: 27 p.

Balen AH, Conway GS, Kaltsas G, et al. Hum Reprod 1995; 10(8):2107-2111.

Aal AbdEl, Mohamed DE, Amine SA, et al. Eur J Obstet Gynecol Reprod Biol 2005; 118(2):219-224. doi: http://dx.doi.org/10.1016/j.ejogrb.2004.07.024

Speca S, Napolitano C, Tagliaferri G. J Ultrasound 2007; 10(4):153-160. doi: http://dx.doi.org/10.1016/j.jus.2007.09.006

Al-Rab MTG, Mohammed ABF, Hassanb MM, et al. Meddle East Fertil Soc J 2015; 20(3):138-143. doi: http://dx.doi.org/10.1016/j.mefs.2014.04.007

Adali E, Kolusari A, Adali F, et al. Int J Gynaecol Obstet 2009; 105:154-157. doi: http://dx.doi.org/10.1016/j.ijgo.2008.12.023

Agrawal R, Conway G, Sladkevicius P, et al. Fertil Steril 1998; 70(4):651-658. doi: http://dx.doi.org/10.1016/S0015-02829800249-0

Dickey R. Hum Reprod Update 1997; 3(5):467-503. doi: http://dx.doi.org/10.1093/humupd/3.5.467

Clapp C, Thebault S, Jeziorski M, Gonzolo E. Physiol Rev 2009; 89(4):1177-1215. doi: http://dx.doi.org/10.1152/physrev.00024.2009

Lonn E, Yusuf S, Arnold M J, Sheridan P. N Engl J Med2006; 354(5):1567-1577.

Voronenko NJu. Eksperym i Klinich Medycyna 2013; 59(2):136-149.

Catteau-Jonard S, Jamin SP, Leclerc A, et al. J Clin Endocrinol Metab2008; 93(11):4456-4461. doi: http://dx.doi.org/10.1210/jc.2008-1231

Dumont A, Robin G, Catteau-Jonard S, Dewailly D. Reprod Biol Endocrinol2015; 13(1):137-147. doi: http://dx.doi.org/10.1186/s12958-015-0134-9

Danforth DR, Arbogast LK, Ghosh S, Friedman CI. Biol Reorod 2003; 68(5):1736-1741. doi: http://dx.doi.org/10.1095/biolreprod.101.000679

Kaczmarek MM, Schams D, Ziecik AJ. Reprod Biol 2005; 5(2):111-136.

Downloads

Published

2021-06-24

How to Cite

Arkhypkina, T. L., Karachentsev, Y. I., Lyubimova, L., Abdullaev, R., & Bondarenko, V. A. (2021). THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE PATHOGENESIS OF POLYCYSTIC OVARY SYNDROME (literature review and own result ). Problems of Endocrine Pathology, 58(4), 91-104. https://doi.org/10.21856/j-PEP.2016.4.12

Most read articles by the same author(s)

1 2 3 > >>