LEVELS OF CATECHOLAMINURIA IN NEWBORNS IN THE FIRST DAYS OF LIFE

Authors

  • Riga O. O. Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2011.3.07

Keywords:

adrenaline, norepinephrine, dopamine, urine, newborn children

Abstract

In the urine of 80 newborns with different birth weights, the concentrations of adrenaline, norepinephrine and dopamine were determined. Analysis of the results of the study showed an increased excretion of dopamine in the urine compared with adrenaline and norepinephrine. The revealed significant increase in the level of adrenaline in the urine of newborns with an unfavorable course of the early neonatal period compared with healthy newborns indicates the activation of the sympathoadrenal system and the adrenal medulla in critical conditions. Determination of the level of adrenalinuria in newborns can be a diagnostic and prognostic marker of a critical condition.

References

Ганонг, Вiльям Ф. Фiзiологiя людини [Текст] / Вiльям Ф. Ганонг. // Львiв: БаК, 2002. — 784 с.

Slotkin, T. A. Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival [Text] / T. A. Slotkin, F. J. Seidler // J. Dev. Physiol. — 1988. — Vol. 10 (1). — P. 1–16.

Neonatal pattern of adrenergic metabolites in urine of small for gestational age and preterm infants [Text] / Y. Dalmaz, L. Peyrin,

J. Dutruge [et al.] // J. Neural. Transm. — 1980. — Vol. 49 (3). — P. 151–65.

Johansson, S. Increased catecholamines and heart rate in children with low birth weight: perinatal contributions to sympathoadrenal overactivity [Text] / S. Johansson, M. Norman, L. Legnevall [et al.] // J. Intern. Med. — 2007. — Vol. 261 (5) — P. 480– 487.

Correlations between urinary excretion of catecholamines and electrocardiographic parameters of vagal hyperreactivity in infants with fainting spells. Implication of sympathetic hypotonia? [Text] / C. O. Leroy-Bouchereau, P. Urios, A. M. Borsos [et al.] // Arch. Cardiovasc. Dis. — 2010. — Vol. 103 (8–9). — P. 430–436.

Schwab, K. O. Inappropriate secretion of umbilical plasma catecholamines in preterm compared to term neonates [Text] / K. O. Schwab, B. Breitung, H. B. von Stockhausen // J. Perinat. Med. – 1996. — Vol. 24 (4). — P. 373–380.

Catecholamine response at birth in preterm newborns [Text] / P. L. Mehandru, B. G. Assel, I. F. Nuamah [et al.] // Biol. Neonate. — 1993. — Vol. 64 (2–3). — P. 82–88.

Systemic and regional hemodynamic effects of highdose epinephrine infusion in hypoxic piglets resuscitated with 100 % oxygen [Text] / P. Y. Cheung, S. Abozaid, Z. Al-Salam [et al.] // Shock. — 2007. — Vol. 28 (4). — P. 491–497.

Steinberg, C. Pharmacokinetics of cardiovascular drugs in children. Inotropes and vasopressors [Text]

/ C. Steinberg, D. A. Notterman // Clin. Pharmacokinet. — 1994. — Vol. 27 (5). — P. 345–367.

Seri, I. Controversies in the diagnosis and management of hypotension in the newborn infant [Text] / I. Seri, J. Evans // Curr. Opin. Pediatr. — 2001. — Vol. 13 (2). — P. 116–123.

Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates [Text] / I. Seri, G. Rudas, Z. Bors [et al.] // Pediatr. Res. — 1993. — Vol. 34 (6). — P. 742– 749.

Seri, I. Systemic and Pulmonary Effects of Vasopressors and Inotropes in the Neonate [Text] / I. Seri // Biol. Neonate. — 2006. — Vol. 89. — P. 340–342.

Dopamine versus epinephrine for cardiovascular support in low birth weight infants: analysis of systemic effects and neonatal clinical outcomes [Text] / E. Valverde, A. Pellicer, R. Madero [et al.] // Pediatrics. — 2006. — Vol. 117 (6). — P. 1213–1222.

Regional hemodynamic effects of dopamine in the indomethacin-treated preterm infant [Text] / I. Seri, S. Abbasi, D. C. Wood, J. S. Gerdes // J. Perinatol. — 2002. — Vol. 22 (4). — P. 300–305.

Lynch, S. K. The effect of dopamine on glomerular filtration rate in normotensive, oliguric premature neonates [Text] / S. K. Lynch, K. V. Lemley, M. J. Polak // Pediatr. Nephrol. — 2003. — Vol. 18 (7). — P. 649–652.

Labaune, J. M. Age-related modulation of dopamine d1 receptor mRNA level by hypoxia in rabbit adrenal gland [Text] / J. M. Labaune, M. J. Boutroy, A. Bairam // Biol. Neonate. — 2003. — Vol. 83 (3). — P. 217–223.

Baserga, C. M. Different Doses of Dopamine Have Heterogeneous Effects on Cerebral Hemodynamics and Dopamine Receptors in Young Rabbits as Measured with Near Infrared Spectroscopy [Text] /M. C. Baserga, C. Bertolotto, A. Sola // Biol. Neonate. — 2005. — Vol. 87. — P. 229–235.

Dopamine Infusion and Anterior Pituitary Gland Function in Very Low Birth Weight Infants [Text] / Luca Filippi, Marco Pezzati, Alessandra Cecchi [et al.] // Neonatology. — 2006. — Vol. 89 (4). — P. 274–280.

Fukuda, S. Correlation between function of the pituitary-thyroid axis and metabolism of catecholamines by the fetus at delivery [Text] / S. Fukuda // Clin. Endocrinol. (Oxf). — 1987. — Vol. 27 (3). — P. 331– 338.

Moftaquir-Handaj, A. Neonatal catecholamine content of adrenal and extra-adrenal chromaffin tissue after prenatal exposure to dexamethasone [Text] / A. Moftaquir-Handaj, S. Jafari, M. J. Boutroy // Pediatr. Res. — 1999. — Vol. 45 (1). — P. 60–65.

Maxwell G. M. Urinary catecholamine levels in the newborn infant [Text] / G. M. Maxwell, S. Crompton, A. Davies // Europ. J. Pediatr. — 1985. — Vol. 143 (3). — P. 171–174.

Ворохобина, Н. В. Заболевания надпочечников [Текст] / Н. В. Ворохобина, П. А. Сильницкий. — СПб.: Изд-во Политех. ун-та, 2009. — 330 с.

Downloads

Published

2011-09-27

How to Cite

Riga, O. O. (2011). LEVELS OF CATECHOLAMINURIA IN NEWBORNS IN THE FIRST DAYS OF LIFE. Problems of Endocrine Pathology, 37(3), 44-50. https://doi.org/10.21856/j-PEP.2011.3.07

Issue

Section

CLINICAL ENDOCRINOLOGY