DETERMINATION OF SODIUM-IODIDE SYMPORTER E XPRESSION IN WELL-DIFFERENTIATED PAPILL ARY CARCINOMAS AND FOLLICULAR NEOPLASMS OF THE THYROID GLAND

Authors

  • Sazonov M. Ye. SI «V. Danilevskiy Institute for Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2017.4.03

Keywords:

thyroid gland cancer, sodium-iodide symporter, radioiodine therapy.

Abstract

The main method for treating well-differentiated thyroid cancer (TC) is radical surgical treatment followed by radioiodine therapy (RIT), which efficacy depends on the ability of the cell to accumulate the radiopharmaceutical agent. Ability to trap iodine is determined by presence of the sodium-iodide symporter protein (NIS) on the cell membrane, which may be lost during carcinogenesis. The level of NIS expression in well-differentiated papillary TC and follicular neoplasms, including both benign and malignant tumors, was studied. Up to 12 % of all papillary carcinomas and 56 % of follicular carcinomas demonstrate absence of NIS expression, which suggests possible insensitivity to RIT and increased risk of disease relapse.

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Published

2017-10-30

How to Cite

Сазонов, М. Є. (2017). DETERMINATION OF SODIUM-IODIDE SYMPORTER E XPRESSION IN WELL-DIFFERENTIATED PAPILL ARY CARCINOMAS AND FOLLICULAR NEOPLASMS OF THE THYROID GLAND. Problems of Endocrine Pathology, 62(4), 23-28. https://doi.org/10.21856/j-PEP.2017.4.03

Issue

Section

CLINICAL ENDOCRINOLOGY