THE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME

Authors

  • Zagayko A. L. National university of pharmacy, Kharkiv
  • Briukhanova T. O. National university of pharmacy, Kharkiv
  • Shkapo A. I. National university of pharmacy, Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2016.2.09

Keywords:

metabolic syndrome, quercetin, epigallocatechin gallate, sex steroids, cortisol

Abstract

It was established the experimental metabolic syndrome development in males of Syrian Golden hamsters on the background of the hypercaloric diet for 5 weeks. Pathological changes of metabolic links manifested by insulin resistance, a decrease in the content of adiponectin, hypercortisolaemia, leptinresistance and imbalance of sex hormones. The administration of the investigated compounds — quercetin and epigallocatechin gallate largely correct these changes. Epigallocatechin gallate had more expressive effect than quercetin.

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Published

2016-06-08

How to Cite

Zagayko, A. L., Briukhanova, T. O., & Shkapo, A. I. (2016). THE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME. Problems of Endocrine Pathology, 56(2), 60-66. https://doi.org/10.21856/j-PEP.2016.2.09