FEATURES OF AGE-RELATED CHANGES AND GROWTH RATES OF THE INCIDENCE OF ENDOCRINE ORGANS’ CANCER IN THE POPULATION OF UKRAINE.
Keywords:endocrine disrupters, thyroid, breast, prostate, uterine body, ovary cancer, sex - age features
The aim: to determine the age characteristics and dynamics of changes in the rate of development of the main hormone-dependent forms of cancer among Ukrainian population.
Materials and methods. Analysis of the dynamic characteristics of age-related changes in the development of endocrine organs’ oncological diseases (cancer of the breast, thyroid and prostate, ovaries and uterine body) among the population was carried out according to the official materials of the Cancer registry of Ukraine covering the period 2000-2018. Standardized incidence rates per 100,000 population, determined according to the Ukrainian standard, were taken into account. The influence of environmental factors and living conditions was determined indirectly by dividing the territory of Ukraine into monitoring zones according to the criterion of indicators of priority forms of economic activity. Statistical information was processed using statistical methods generally accepted in biomedical research and Student's t-test.
Results. The dependence of qualitative and quantitative formation characteristics of malignant neoplasms of the endocrine organs on the territory and living conditions of the population was revealed. Dynamic secular changes indicate that each subsequent observation period is characterized by a higher incidence rate and a pronounced trend towards an earlier appearance of the first neoplasm.
Conclusion. Based on the results of dynamic studies covering a 20-year period, a stable increase in the incidence of endocrine organs’ oncopathology has been established in the population. It is shown that each subsequent observation period is characterized by a higher incidence rate and a pronounced tendency to an earlier manifestation of the first neoplasm. The results obtained are recommended to be taken into account when organizing and conducting medical examinations, medical work and in the field of preventive medicine.
Antonenko AM, Korshun MM. Dovkillja ta zdorov’ja 2017;1(81): 59-64. https://doi.org/10.32402/dovkil2017.01.059.
Vavrinevych OP. Dovkillja ta zdorov’ja. 2019;1(90): 4-9. https://doi.org/10.32402/dovkil2019.01.004.
Endokrynni rujnivnyky v Ukrai’ni: stan problemy ta shljahy i’i’ vyrishennja: Nacional’nyj ogljad, Kyi’v, 2018: 156 p.
Chernychenko IO, Lytvychenko OM, Tsymbaliuk SM, et al. Probl Endokryn Patolohii 2020;1: 72-77. https://doi.org/10.21856/j-PEP.2020.1.10.
A selection of bulletins of the National Cancer Register of Ukraine "Morbidity, mortality, indicators of the cancer service" for 2000-2018, available at: http://www.ncru.inf.ua/.
Antonomov Myu. Mathematical processing and analysis of medico-biological data. 2 ed, Kiev, 2018: 579 p.
Tarapore P, Ying J, Ouyang B, et al. PLoS One 2014;9(3): 339-350. https://doi.org/10.1371/journal.pone.0090332.
Terry M, Michels K, Brody J, et al. Breast Cancer Res 2019;21: 96-99. http://dx.doi.org/10.1186/s13058-019-1168-2.
Gibson DA, Saunders PT. Endocr Relat Cancer 2014;21(2): 13-31. https://doi.org/10.1530/ERC-13-0342.
Rochefort H. Comptes Rendus Biologies 2017;340(9-10): 439-445. https://doi.org/10.1016/j.crvi.2017.07.007.
Gore AC, Chappell VA, Fenton SE, et al. Endocr Rev 2015;36(6): 593-602. https://doi.org/10.1210/er.2015-1093.
Benedetti M, Zona A, Beccaloni E, et al. Int J Environ Res Public Health 2017;14(4): 355-366. http://doi.org/10.3390/ ijerph14040355.