FEATURES OF AGE-RELATED CHANGES AND GROWTH RATES OF THE INCIDENCE OF ENDOCRINE ORGANS’ CANCER IN THE POPULATION OF UKRAINE.

Authors

  • Chernychenko I. O. SI “O.M. Marzeiev Institute of public health of the National Academy of Medical Sciences of Ukraine” https://orcid.org/0000-0002-4784-4628
  • Lytvychenko O. M. SI “O.M. Marzeiev Institute of public health of the National Academy of Medical Sciences of Ukraine”
  • Babiy V. F. SI “O.M. Marzeiev Institute of public health of the National Academy of Medical Sciences of Ukraine” https://orcid.org/0000-0003-2519-1440
  • Tsymbaliuk S. M. Kyiv City Clinical Endocrinology Center of MH of Ukraine https://orcid.org/0000-0002-9911-6593
  • Kondratenko O. Ye. SI “O.M. Marzeiev Institute of public health of the National Academy of Medical Sciences of Ukraine”
  • Hlavachek D. O. SI “O.M. Marzeiev Institute of public health of the National Academy of Medical Sciences of Ukraine” https://orcid.org/0000-0002-0512-6927

DOI:

https://doi.org/10.21856/j-PEP.2022.3.07

Keywords:

endocrine disrupters, thyroid, breast, prostate, uterine body, ovary cancer, sex - age features

Abstract

The aim: to determine the age characteristics and dynamics of changes in the rate of development of the main hormone-dependent forms of cancer among Ukrainian population.

Materials and methods. Analysis of the dynamic characteristics of age-related changes in the development of endocrine organs’ oncological diseases (cancer of the breast, thyroid and prostate, ovaries and uterine body) among the population was carried out according to the official materials of the Cancer registry of Ukraine covering the period 2000-2018. Standardized incidence rates per 100,000 population, determined according to the Ukrainian standard, were taken into account. The influence of environmental factors and living conditions was determined indirectly by dividing the territory of Ukraine into monitoring zones according to the criterion of indicators of priority forms of economic activity. Statistical information was processed using statistical methods generally accepted in biomedical research and Student's t-test.

Results. The dependence of qualitative and quantitative formation characteristics of malignant neoplasms of the endocrine organs on the territory and living conditions of the population was revealed. Dynamic secular changes indicate that each subsequent observation period is characterized by a higher incidence rate and a pronounced trend towards an earlier appearance of the first neoplasm.

Conclusion. Based on the results of dynamic studies covering a 20-year period, a stable increase in the incidence of endocrine organs’ oncopathology has been established in the population. It is shown that each subsequent observation period is characterized by a higher incidence rate and a pronounced tendency to an earlier manifestation of the first neoplasm. The results obtained are recommended to be taken into account when organizing and conducting medical examinations, medical work and in the field of preventive medicine.

References

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Published

2022-09-15

How to Cite

Черниченко, І., Литвиченко, О., Бабій, В., Цимбалюк, С., Кондратенко, О., & Главачек, Д. (2022). FEATURES OF AGE-RELATED CHANGES AND GROWTH RATES OF THE INCIDENCE OF ENDOCRINE ORGANS’ CANCER IN THE POPULATION OF UKRAINE. Problems of Endocrine Pathology, 79(3), 53-58. https://doi.org/10.21856/j-PEP.2022.3.07

Issue

Section

CLINICAL ENDOCRINOLOGY