NEW APPROACHES TO COMPLEX CORRECTION HYPOTHYROIDISM AND ITS RELATED COMPLICATIONS
DOI:
https://doi.org/10.21856/j-PEP.2016.4.10Keywords:
thyroid, bone, hypothyroidism, osteoporosis, endocrine, chemical compoundsAbstract
It was studied the specific multipotent performance synthetic compounds with a number of tryazolopyrymides 7-(3-hydroxyphenyl)-6-carbetoxy-5-methyl-4,7-dihydro[1,2,4]triazolo [1,5-a]pyrymidyn (NE-99) in thyroid and skeletal system of Wistar rats with experimental hypothyroidism. It was proved the positive effect of the compound YV-99 on the structure and functions of the thyroid gland and found it osteoprotect effect on bone lumbar vertebrae experimental animals. The obtained data allow us to consider this compound as a comprehensive tool to correct hypothyroidism thyroid and endocrine concomitant osteoporosis.
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