STUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS

N. G. Malova; L. A. Sirotenko; I. V. Komarova; E. S. Anikeeva; A. V. Spiridonov; A. N. Sova; Volodimir Vakula; F. G. Yaremenko

doi:10.21856/j-PEP.2016.3.05

STUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS

Authors

Malova N. G. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Sirotenko L. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Komarova I. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Anikeeva E. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Spiridonov A. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Sova A. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
Vakula V. N. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv https://orcid.org/0000-0001-8392-2219
Yaremenko F. G. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2016.3.05

Keywords:

immune system, thyroid function, autoimmune thyroiditis, imidazo[2,1- b]thiazoles.

Abstract

The study of new biologically active compound PL-308 with immunomodulating properties on the thyroid function in rats with experimental autoimmune thyroiditis. It was determined that the introduction of PL-308 reduces autoimmune aggression by lowering the level of antibodies to thyroglobulin, increases the number of all subpopulations of T-lymphocytes, in particular Tsuppressors. It was observed normalization of the functional state of the thyroid gland.

References

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Published

2016-08-17

How to Cite

Malova, N. G., Sirotenko, L. A., Komarova, I. V., Anikeeva, E. S., Spiridonov, A. V., Sova, A. N., … Yaremenko, F. G. (2016). STUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS. Problems of Endocrine Pathology, 57(3), 43–49. https://doi.org/10.21856/j-PEP.2016.3.05

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Vol. 57 No. 3 (2016): Problems of Endocrine Pathology

Section

EXPERIMENTAL STUDIES

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STUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS

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