The impact of exogenous estrogens on biochemical markers of endothelial dysfunction in diabetic rats with hypoestrogenia
DOI:
https://doi.org/10.21856/j-PEP.2017.1.05Keywords:
type 2 diabetes, estrogen deficiency, endothelial dysfunction, estradiol derivativeAbstract
It was investigated the impact of selective estrogen receptor modulator PE0607 comparing to 17β-estradiol on the biochemical markers of endothelial dysfunction in ovariectomized rats with type 2 diabetes. It was established that injection of PE0607 as well as 17β-estradiol decreases lipid peroxidation first products in serum and increases serum whole antioxidant activity and NO-synthase activity in vessels of experimental rats. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for prevention and treatment of diabetic cardiovascular disorders in women with hypoestrogenia.
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