THE ROLE OF COMPONENTS OF THE EXTRACELLULAR MATRIX IN THE DEVELOPMENT OF ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2 (literature review)

Authors

  • Koteliukh M. Yu. Kharkiv National Medical University, Department of internal medicine № 2, clinical immunology and allergology
  • Kravchun P. G. Kharkiv National Medical University, Department of internal medicine № 2, clinical immunology and allergology

DOI:

https://doi.org/10.21856/j-PEP.2015.4.13

Keywords:

acute myocardial infarction, diabetes mellitus type 2, extracellular matrix, cardiovascular complications

Abstract

The article highlights the influence of matrix metalloproteinases, tissue inhibitors of metalloproteinases and tenascin C onto development and severity of the acute myocardial infarction in the patients with comorbide pathology. It was determined that the levels of matrix metalloproteinases were decreasing, and tissue inhibitors of metalloproteinases were raising in the patients with cardiovascular disease depending on the presence or absence of diabetes mellitus type 2. The attention was compelled to the ability of the extracellular matrix indicators to implement remodeling of the left ventricular myocardium in the patients with acute myocardial infarction and its complications. Here was exposed the changes in the parameters of the patients that have confirmed a promising study of their predicting properties at the development of cardiovascular complications in the patients with the acute myocardial infarction with concomitant diabetes mellitus type 2.

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Published

2021-08-10

How to Cite

Koteliukh, M. Y., & Kravchun, P. G. (2021). THE ROLE OF COMPONENTS OF THE EXTRACELLULAR MATRIX IN THE DEVELOPMENT OF ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2 (literature review). Problems of Endocrine Pathology, 54(4), 111-118. https://doi.org/10.21856/j-PEP.2015.4.13

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