IRON METABOLISM, ERYTHROPOIESIS AND IMMUNE INFLAMMATION IN ANEMIC PATIENTS WITH CHRONIC HEART FAILURE IN THE PRESENCE OF DIABETIC NEPHROPATHY
DOI:
https://doi.org/10.21856/j-PEP.2016.2.06Keywords:
chronic heart failure, anemia, diabetic nephropathy, iron metabolism, immune inflamationAbstract
The development of anemia in patients with chronic heart failure by the presence of diabetic
nephropathy is characterized by erythropoietyc activity fall due to the low level of erythropoietin
and functional iron deficiency, as a result of influence of pro-inflammatory cytokine level on hepcidin
activity, resulting in the disruption of the functional iron fund, deposited block of iron. The presence
of microalbuminaemia can be considered as a factor in formation of anemic syndrome due to loss of
erythropoietin, transferrin, soluble transferring receptor as a part of protein’s pool in patients with
chronic heart failure and diabetic nephropathy. The presence of anemia in patients with chronic heart
failure and diabetic nephropathy is associated with inadequate low central regulator of erythropoiesis
level in response to low hemoglobin concentrations on background of moderate decrease in glomerular
filtration rate.
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