CORRELATION OF INFLAMMATION WITH STRUCTURAL AND FUNCTIONAL CHANGES IN THE RATS’ PROSTATE GLAND WITH CHRONIC PROSTATITIS UNDER THE EXPOSURE OF CHONDROITIN SULPHATE
Keywords:non-bacterial prostatitis, Chondroitin sulfate, Prostaplant forte, connective tissue, inflammation
According to statistics, about 10 % of urological patients in Ukraine have diagnose as well chronic prostatitis/chronic pelvic pain syndrome, or non-bacterial chronic prostatitis. The etiology and pathogenesis continue to be substantially uncertain, but inflammation is one of the triggers that also involves connective tissue. The aim of the work was to evaluate and compare changes of inflammation markers and histological structure of prostate tissue in rats with experimental chronic prostatitis under conditions of Chondroitin sulfate use.
Material and Methods. Non-bacterial prostatitis was caused by local irrigation of the previously exposed surgical access to isthmus and ventral parts of the prostate for 5 seconds by an applicator for the wart removal Wartner®, the wounded surface was sewed in afterwards. Non-bacterial prostatitis was caused by local irrigation of the previously exposed surgical access to isthmus and ventral parts of the prostate for 5 seconds by an applicator for the wart removal Wartner®, the wounded surface was sewed in afterwards. To assess the anti-inflammatory and prostatoprotective properties, we used the introduction of the substance Chondroitin sulfate (manufactured by Sigma, USA) and the reference drug Prostoplant forte (manufactured by Schwabe, Germany). The drugs were administered three days before the simulation of cryotraumatic prostatitis and within 11 days after cryotrauma. The state of inflammation was assessed by the level of C-reactive protein, the number of leukocytes, the erythrocyte sedimentation rate in the blood, and during pharmacological correction. The state of the connective tissue was assessed according to the results of histological examination of the prostate.
The results of the laboratory and histological studies in the conditions of simulating prostatopathy have been shown that markers of inflammation of the blood and prostate tissue have parallel unidirectional changes. Both drugs have a distinct anti-inflammatory effect and they are able to protect prostate tissue from destructive changes resulting from inflammation. The effectiveness of Chondroitin sulfate did not concede to the comparison drug Prostoplant forte, and was even partly more effective in normalizing the concentration of C-reactive protein C-reactive protein and reconstruction of prostate tissue. Conclusion. These results indicate that the use of a combination of prostatoprotectors and drugs capable of affecting the metabolism and reconstruction of connective tissue is promising for the treatment of prostatitis.
Zhang R, Chomistek AK, Dimitrakoff JD, et al. Med Sci Sports Exerc 2015;47(4): 757-764. https://doi.org/10.1249/MSS.0000000000000472.
Berger RE. J Urol 2011;170(17): 1219-1224. https://doi.org/10.1001/archinternmed.2010.319.
Nickel JC, Alexander RB, Schaeffer AJ, et al. J Urol 2003;170(3): 818-822. https://doi.org/10.1097/01.ju.0000082252.49374.e9.
Franco JV, Turk T, Jung JH, et al. Cochrane Database Syst Rev 2018;1(1): CD012551. https://doi.org/10.1002/14651858.CD012551.pub2.
Franco JVA, Turk T, Jung JH, et al. BJU Int 2020;125(4): 490-496. https://doi.org/10.1111/bju.14988.
Doklinichni doslidzhennnja likars’kyh zasobiv : metodychni rekomendacii’ / za red. O. V. Stefanova, Kyi’v, 2001: 528 p.
Zajchenko GV, Andrijanenkov OV, Gevojan SR, Soldatova JeO. Novitni pidhody do modeljuvannja kriotravmy peredmihurovoi’ zalozy v eksperymenti : inform. lyst, Kyi’v, 2013: 4 p.
Patent 38911 UA. Sposib vyznachennja koncentracii’ S-reaktyvnogo bilka ekspres-metodom.
Merkulov GA. Kurs patologogistologicheskoj tehniki, Moskva, 1969: 424 р.