RELATIONSHIP BETWEEN BLOOD LIPIDS AND VITAMIN D STATUS IN ADOLESCENT GIRLS WITH OLIGOMENORRHEA
Keywords:lipid profile, oligomenorrhea, adolescent girls, vitamin D
Purpose: to assess the relationship between the level of vitamin D in blood serum and lipid profile in patients with oligomenorrhea.
Materials and methods: 62 teenage 12-18 years old girls with oligomenorrhea were examined. Concentration of 25(OH)D, total cholesterol (CH), high-density lipoprotein cholesterol (HDL cholesterol), triglycerides (TG), β-lipoproteins were determined on an empty stomach in serum. LDL cholesterol, VLDL cholesterol and atherogenic coefficient (AC) were calculated. Adolescents were divided into 2 groups depending on the BMI. I gr. were patients with low body weight, II gr. - with normal body weight.
Results. Only 34.8% of adolescents with oligomenorrhea did not show any changes in the lipid profile. More than a third (32.8%) of the examined patients had an increase in the level of CH, both in girls with physiological parameters of BMI and in its deficiency. Almost 60% of adolescents have an increase in β-lipoproteins. An increase in the level of TG and AC was registered in 17.4%, and elevated LDL cholesterol levels was detected in 13.0%. Almost every fifth (19.6%) patient had combined disorders of the blood lipid spectrum.
More than 80% of the girls with oligomenorrhea had a decrease in blood levels of vit. D, and half of them had less than 20 ng/ml vit. D. Only 17.3% of adolescents with OM had vit. D values above 30 ng/ml. No significant differences between the groups were found. The increase in atherogenic fractions of lipoproteins is registered against the background of declining concentrations of vit. D, the risk of formation of dyslipidemias also increases. The factor model of association of lipids and vit. D is constructed, which confirms the negative dependence of the blood level of vit. D and triglycerides and LDL cholesterol.
Conclusions. Vitamin D levels affect lipid levels in girls with oligomenorrhea. Changes in the blood lipid spectrum and the number of adolescents with atherogenic changes in the lipid profile increase against the background of declining levels of vit. D. Decreased level of vitamin D and disorders of the lipid profile in girls should be the objects of primary prevention due to the high risk of metabolic and cardiometabolic disorders in the future.
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