PECULIARITIES OF THE ORGANISM'S REACTION TO DOSED HYPOXIA IN ELDERLY PEOPLE WITH IMPAIRED GLUCOSE TOLERANCE
Keywords:carbohydrate tolerance, insulin, glucose, hypoxia resistance, aging
Background. The incidence of carbohydrate metabolism disorders increases with age, resulting in a significantly increased risk of cardiovascular disease. Hypoxia plays an important role in the pathogenesis of carbohydrate metabolism disorders. The aim – to establish the features of carbohydrate metabolism in hypoxia in the elderly with impaired carbohydrate tolerance.
Materials and methods. 20 elderly people with impaired glucose tolerance and 23 elderly people with preserved glucose tolerance were examined. Determined the concentration of glucose and insulin in the blood when breathing air with an oxygen content of 12%.
Results. With hypoxia in people with impaired glucose tolerance, the decrease in saturation is more significant than in people with preserved glucose tolerance. Shifts in glucose concentration in hypoxia in people with impaired glucose tolerance are greater, but the ratio of Δ glucose concentration/ΔSpO2 is higher than in people with preserved glucose tolerance. Shifts in the concentration of insulin in the blood during hypoxia did not differ in people with different glucose tolerance, but the ratio of Δinsulin concentration /ΔSpO2 in people with impaired glucose tolerance is less. In people with impaired glucose tolerance, a relationship was found between glucose levels after 120 minutes of glucose tolerance test and SpO2 shifts in hypoxia, as well as a relationship between HOMA index and SpO2 shifts in hypoxia.
Conclusions. Elderly people with impaired glucose tolerance have reduced resistance to hypoxia and increased utilization of glucose in hypoxia, due to smaller changes in insulin concentrations. At the same time at them disturbance of a carbohydrate metabolism depends on resistance to a hypoxia.
La Vignera S, Aversa A, Monzani F. Endocrine Frailty in the Elderly, Lausanne: Frontiers Media SA, 2019: 147 p. https://doi: 10.3389/978-2-88963-234-3.
Smith NL, Savage PJ, Heckbert SR, et al. J Am Geriat Soc 2002;50: 416-423.
Nyengaard JR, Ido Y, Kilo C, Williamson JR. Diabetes 2004;53(11): 2931-2938. https://doi.org/10.2337/diabetes.53.11.2931
Mansor LS, Mehta K, Aksentijevic D, et al. J Physiol 2015;17: 307-320. https://doi.org/10.1113/JP271242
Polak J, Shimoda LA, Drager LF, et al. Sleep 2013;36(10): 1483-1490. https://doi.org/10.5665/sleep.3040
Chyzhova VP. Dr. of medical sci. diss, Kiev:DU «In-t of gerontology named by D.F. Chebotarev NAMS of Ukraine», 2019; 509 p.
Korkushko OV, Shatilo VB, Chizhova VP, et al. Fіzіol. zhurn 2016;62(1): 33-41.
Diagnosis and classification of diabetes mellitus. American diabetes association. Diabetes Care 2004;27(l): S62-S69. https://doi.org/10.2337/dc14-S081
Patent 7845 UA. Sposib viznachennja stіjkostі organіzmu ljudini do gіpoksії.
Krivoshhekov SG, et al. Fiziologija cheloveka 2014;40(6): 34-45.
McAuley KA, Williams SM, Mann JI. Diabetes Care 2001;24: 460-464.
Erecińska M, Silver IA. Respiration physiology 2001;128(3): 263-276. https://doi.org/10.1016/s0034-5687(01)00306-1
Duelli R, Kuschinsky W. News Physiol. Sci. 2001;16: 71-76. https://doi.org/10.1152/physiologyonline.2001.16.2.71
Drager LF, Jun JC, Polotsky VY, et al. Best Pract Res Clin Endocrinol Metab 2010;24(5): 843-851.
Doumit J, Prasad B. Diabetes Spectrum 2016;29(1): 14-19. https://doi.org/10.2337/diaspect.29.1.14
Cao L, Mao C, Li S, et al. Endocrinology 2012;153(10): 4955-4965.