THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND AUTONOMIC NERVOUS REGULATION IN CONDITIONS OF DOSED HYPOXIA IN THE ELDERLY
DOI:
https://doi.org/10.21856/j-PEP.2023.3.01Keywords:
insulin resistance, autonomic nervous system, hypoxia, agingAbstract
Background. The incidence of diabetes and the incidence of insulin resistance increases with age. The regulation of the autonomic nervous system plays an important role in the processes of carbohydrate metabolism disorders.
Aim. To find out the state of autonomic nervous regulation and its response to dosed hypoxia in elderly people with insulin resistance
Materials and methods. 55 elderly people with impaired glucose tolerance and 30 elderly people with preserved glucose tolerance were examined. The state of regulation of the autonomic nervous system was determined during air inhalation and at 12 % dosed hypoxia.
Results. Vagus activity in normoxia conditions in elderly people with impaired and preserved glucose tolerance did not reliably differ. However, more significant activity of sympathetic influences was observed in people with impaired glucose tolerance. The existence of a statistically significant direct correlation between indicators of carbohydrate metabolism and the state of the sympathetic division of the ANS in elderly people with impaired glucose tolerance was established.
In response to dosed hypoxia, a decrease in the power of all spectral components of heart rate variability is observed in elderly people with both impaired and preserved glucose tolerance. At the same time, uneven reduction of various spectral components of heart rate variability led to a relative predominance of sympathetic activity. However, under conditions of hypoxia in elderly people with impaired glucose tolerance, there was a more significant relative activation of the sympathetic link of the autonomic nervous system.
Conclusions. When glucose tolerance is impaired in the elderly, more significant activity of the sympathetic division of the autonomic nervous system develops. A causal relationship between increased sympathetic activity and insulin resistance in elderly people with impaired glucose tolerance was established. In the development of impaired glucose tolerance in the elderly under conditions of dosed hypoxia, the relative activation of the sympathetic division of the autonomic nervous system is more significant.
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