ANALYSIS OF THE LEFT VENTRICULAR DIASTOLIC DYSFUNCTION PARAMETERS IN PATIENTS WITH HYPERTENSION AND CONCOMITANT TYPE 2 DIABETES MELLITUS

Abstract

The aim of the study. To conduct analyzes of the left ventricular diastolic function in patients with hypertension alone or with concomitant type 2 diabetes mellitus before and after complex treatment with the eplerenone at 50 mg per day and trimetazidine at 80 mg per day.

Materials and methods. 25 patients with hypertension and type 2 diabetes mellitus (T2DM) in a sub-compensated state (main group) and 25 patients with hypertension stage II, without T2DM, aged 35 to 65 years, who were being treated in the clinic of the GI "L. T. Malaya Therapy National Institute of the NAMS of Ukraine". The control group consisted of 20 healthy people.

Statistical analysis of data was performed using the package of statistical programs Statistica, 8.0 (Stat Soft Inc, USA), Microsoft office Excel 2003, using standard methods.

Results and conclusions. Three-month treatment with eplerenone and trimetazidine contributed to the normalization of hemodynamics and metabolic processes, led to improvement of the functional capabilities of the myocardium (increased rate of myocardial relaxation in diastole), inhibition or termination of the further development of adverse changes in cardiohemodynamics in the form of an increase in left ventricular filling pressure and violation of the geometric parameters of the heart. The study of the parameters of the diastolic function of the left ventricle at the stage of functional disorders of the myocardium is necessary in order to prevent or reverse the development of heart failure in patients with comorbid pathology: hypertension with type 2 diabetes, which is the key to improving the cardiovascular prognosis in such a contingent of patients. The conducted research confirms the need for timely diagnosis in order to clarify the mechanisms of development of heart failure in patients with comorbid pathology and to carry out prophylactic treatment of the identified disorders under the conditions of maintaining the state of sub-compensation of carbohydrate metabolism.