androgenic status, diabetes mellitus, vitamin D, body mass index, erectile function, estradiol, testosterone


Some research shows that vitamin D (Vit D) deficiency may contribute to the development of androgen deficiency and erectile dysfunction (ED) among males, including those with diabetes mellitus.

The purpose of the research is to establish the features of changes in erectile function and androgen status depending on the vitamin D level in the blood of males with type 1 and 2 diabetes mellitus.

Materials and methods: there were 65 males of 23-63 years old with diabetes mellitus: 28 male patients with type 1 (T1D) and 37 male patients with type 2 diabetes mellitus (T2D). Body mass index (BMI), testosterone, estradiol (E2) levels, T/E2 ratio, Vit D level in the blood were studied; erectile function (EF) status was determined on the basis of the International Erectile Function Index (ICEF-5).

Results. The analysis of Vit D levels in the blood shows that their average values among male patients with T1D and T2D do not significantly differ. At the same time, the average values of T and T/E2 in the blood among males with T1D were probably higher. The research defines that the formation of D-hypovitaminosis among male patients with T2D is connected with the increase in BMI and the incidence of obesity, which is not observed among patients with T1D.

The research finds no correlation between the levels of Vit D and T in the blood within both groups of patients, but there is a positive correlation between the level of Vit D in the blood and the values of the T/E2 ratio among patients with diabetes. Patients of both groups show no correlation between Vit D levels and ICEF-5 score. Meanwhile, there is a positive correlation between the values of androgenization (T level, T/E2 values) and ICEF-5 score among patients with diabetes mellitus.

Conclusions. Males with diabetes, regardless of its type, develop the deficiency of blood vitamin D level. The deficiency of vitamin D among the patients with type 2 diabetes is associated with the increased BMI and obesity. These factors form some contingent of patients with both absolute and relative hypoandrogenemia. D-hypovitaminosis does not lead to the development of androgen deficiency among males with type 1 diabetes mellitus. A predictor of the erectile dysfunction formation among males with type 2 diabetes mellitus is a decrease in testosterone levels in the blood on the background of D-hypovitaminosis.


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How to Cite

Бондаренко, В., Хижняк, О., Саніна, Є., Скорняков, Є., Мінухін, А., Ніколаєв, Р., & Червенко, О. (2022). ANDROGEN STATUS, BLOOD VITAMIN D LEVEL AND STATE OF ERECTILE FUNCTION IN MALES WITH DIABETES MELLITUS. Problems of Endocrine Pathology, 79(4), 14-19.




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