Metabolic disbalance in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease taking into account the single nucleotide polymorphism – 308 G/A of tumor necrosis factor-alpha (TNF) gene
DOI:
https://doi.org/10.21856/j-PEP.2018.1.04Keywords:
single nucleotide polymorphism, tumor necrosis factor-alpha gene, type 2 diabetes, nonalcoholic fatty liver diseaseAbstract
Polymorphism of tumor necrosis factor-alpha gene (TNF) in in the promoter region - 308 G/A was studied. For this research we used blood samples of 118 patients with T2DM and 50 healthy habitants of Kharkiv. There were no significant differences in allele frequencies for single nucleotide polymorphism -308 G/A in patients with type 2 diabetes (рG = 0,858, qА = 0,142) and and healthy individuals (рG = 0,930, qА = 0,070). Stratification of the type 2 diabetic patients in the presence and absence of NAFLD showed a more pronounced increase in circulatory levels of TNF-α in patients with NAFLD. The obtained data have proved promising for further research, which should be use this indicator as a diagnostic parameter of the above complication. In our study, there was no relationship between TNFα-308 polymorphism and the risk of NAFLD. Nevertheless, we have found a tendency for the harmful effects of the - 308A allele on lipid levels in patients with type 2 diabetes in the presence of NAFLD, suggesting that TNFα-308 A-alleles may contribute to insulin resistance in patients, which in turn may increase the risk of complications.
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