Metabolic disbalance in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease taking into account the single nucleotide polymorphism – 308 G/A of tumor necrosis factor-alpha (TNF) gene

Authors

  • Karachentsev Y. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine; Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine
  • Poltorak V. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Atramentova L. O. V. N. Karazin Kharkiv national university, Kharkiv, Ukraine
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy, Kharkiv, Ukraine
  • Tyzhnenko T. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Zh. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Jаnsen E. National Institute for Public Health and the Environment, Bilthoven, The Netherlands
  • Pochernyayev A. K. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Cherniaieva A. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Plohotnichenko O. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine
  • Mishchenko T. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2018.1.04

Keywords:

single nucleotide polymorphism, tumor necrosis factor-alpha gene, type 2 diabetes, nonalco­holic fatty liver disease

Abstract

Polymorphism of tumor necrosis factor-alpha gene (TNF) in in the promoter region - 308 G/A was studied. For this research we used blood samples of 118 patients with T2DM and 50 healthy habitants of Kharkiv. There were no significant differences in allele frequencies for single nucleotide polymorphism -308 G/A in patients with type 2 diabetes (рG = 0,858, qА = 0,142) and and healthy individuals (рG = 0,930, qА = 0,070). Stratification of the type 2 diabetic patients in the presence and absence of NAFLD showed a more pronounced increase in circu­latory levels of TNF-α in patients with NAFLD. The obtained data have proved promising for further research, which should be use this indicator as a diagnostic parameter of the above complication. In our study, there was no relationship between TNFα-308 polymorphism and the risk of NAFLD. Nevertheless, we have found a ten­dency for the harmful effects of the - 308A allele on lipid levels in patients with type 2 diabetes in the presence of NAFLD, suggesting that TNFα-308 A-alleles may contribute to insulin resistance in patients, which in turn may increase the risk of complications.

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Published

2021-06-30

How to Cite

Karachentsev, Y. I., Poltorak, V. V. ., Kravchun, N. O., Atramentova, L. O. ., Gorshunska, M. Y. ., Tyzhnenko, T. V. ., Krasova, . N. S. ., Leshchenko, . Z. A., Jаnsen E. ., Pochernyayev, A. K. ., Gladkih, A. I. ., Cherniaieva, A. A. ., Plohotnichenko, O. O. ., & Mishchenko, T. V. (2021). Metabolic disbalance in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease taking into account the single nucleotide polymorphism – 308 G/A of tumor necrosis factor-alpha (TNF) gene. Problems of Endocrine Pathology, 63(1), 29-41. https://doi.org/10.21856/j-PEP.2018.1.04

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CLINICAL ENDOCRINOLOGY

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