THE RELATIONSHIP BETWEEN METABOLIC PARAMETERS AND THE LEVEL OF INSULIN-LIKE GROWTH FACTOR-1 IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH COMORBID PATHOLOGY

Authors

DOI:

https://doi.org/10.21856/j-PEP.2022.2.03

Keywords:

type 2 diabetes mellitus , non-alcoholic fatty liver disease , obesity , insulin-like growth factor-1

Abstract

Relevance. Type 2 diabetes in clinical practice is often combined with non-alcoholic fatty liver disease and obesity. It is interesting to investigate the mechanisms that are the connecting links in the pathogenesis of the development of the above metabolic disorders. The purpose of the study was to examine the relationship between plasma concentrations of insulin-like growth factor-1 and lipid metabolism in patients with type 2 diabetes and non-alcoholic fatty liver disease with different phenotypes.

Materials and methods. 70 patients were examined, including persons with type 2 diabetes, non-alcoholic fatty liver disease with normal body weight (n = 20), patients with type 2 diabetes, non-alcoholic fatty liver disease with obesity (n = 50), as well as 20 healthy individuals. A complex of clinical, laboratory and instrumental (including puncture liver biopsy in 7 patients) studies was carried out.

Results. The relationship between the level of insulin-like growth factor-1 and lipid metabolism, body mass index has been established. There was a significant decrease in plasma levels of insulin-like growth factor-1 in patients with comorbid pathology.

Conclusion. Decreased levels of insulin-like growth factor-1 and impaired lipid metabolism are closely related in patients with type 2 diabetes mellitus in combination with nonalcoholic fatty liver disease (as evidenced by correlation analysis). This affects the progression of pathological changes in the liver in patients with combined pathology, in particular, in the presence of concomitant obesity in patients. Further study of the additional ways in which insulin-like growth factor-1 exerts its effect will help determine the proper role of insulin-like growth factor-1 in the mechanisms of formation and course of nonalcoholic fatty liver disease in patients with type 2 diabetes.

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Published

2022-06-09

How to Cite

Журавльова, Л., Елхаж, О., & Журавльова , А. (2022). THE RELATIONSHIP BETWEEN METABOLIC PARAMETERS AND THE LEVEL OF INSULIN-LIKE GROWTH FACTOR-1 IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH COMORBID PATHOLOGY . Problems of Endocrine Pathology, 79(2), 19-24. https://doi.org/10.21856/j-PEP.2022.2.03

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Section

CLINICAL ENDOCRINOLOGY