LONG-TERM EFFECTS OF MOTHERS STRESS IN THE FIRST THIRD OF PREGNANCY ON THE STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF PANCREAS IN ADULT OFFSPRINGS
DOI:
https://doi.org/10.21856/j-PEP.2012.4.13Keywords:
gestational stress, offsprings, pancreasAbstract
A comparative study of the levels of corticosterone, histostructure insulin-produced and function of pancreatic islets in adult male rats — offsprings of intact and gestational-stressed mothers in the basal state and after hypokinesia was conducted. Found that in a state of physiological rest concentration of insulin in the offspring of stressed mothers higher than in intact rats. For this group of animals is characterized disproportionate increase in insulin levels increased towards to concentrations of glucocorticoids that regarded as instability of adaptation. By histological studies of pancreatic islets shown the increasing number of islets in the offspring of stressed-mothers while reducing their size. Stress of hypokinesia leads to active formation of new islets and increased insulin levels in the blood plasma stressed offsprings. “Structural and functional consequence” of gestational maternal stress on level of pancreatic islets offsprings considered as a predisposition for the development of the metabolic syndrome and type 2 diabetes.
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