THE EFFECTS OF PRENATAL STRESS ON STRUCTURAL-FUNCTIONAL CONDITION OF FEMALE REPRODUCTIVE SYSTEM IN ADULT OFFSPRING

Aida Gevorkyan; Tatiana Bondarenko; Ihor Volokhov; Yuliya Laryanovska; Natalia Sotnik; Tetiana Bocharova; Iryna Markovych; Kateryna Misiura; Loriana Sergienko

doi:10.21856/j-PEP.2023.4.06

THE EFFECTS OF PRENATAL STRESS ON STRUCTURAL-FUNCTIONAL CONDITION OF FEMALE REPRODUCTIVE SYSTEM IN ADULT OFFSPRING

Authors

Gevorkyan A. R. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0009-0009-7502-2216
Bondarenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0009-0001-9548-7928
Volokhov I. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0001-6138-5889
Laryanovska Yu. B. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-4164-9415
Sotnik N. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
Bocharova T. V. Kharkiv International Medical University, Kharkiv, Ukraine https://orcid.org/0000-0002-2264-1744
Markovych I. H. Scientific coordination management National Academy of Medical Sciences of Ukraine, Kiev, Ukraine https://orcid.org/0000-0002-0688-4746
Misiura K. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-0258-9109
Sergienko L. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-1474-222X

DOI:

https://doi.org/10.21856/j-PEP.2023.4.06

Keywords:

prenatal stress, reproductive system, sex hormones, ovary morphology

Abstract

The prenatal period of human development is the most vulnerable. Events in the life of a pregnant woman, in particular socio-emotional stress, make influence on the intrauterine fetus development but also on the health of the child and his susceptibility to certain diseases in adult. To date, it has been proven that the reproductive system, starting from the embryonic period to the end of the descending ontogenesis, is particularly sensitive to the effects of socio-emotional stress. The aim of study is to define effects of social-emotional maternal stress during prenatal period on morpho-functional condition of the ovaries in the adult offspring.

Materials and methods. 10-month-old female Wistar rats from the first-generation descendants of control females and socio-emotional stressed during the pregnancy mothers were investigated in the experiment. Histological changes in ovaries as well as hormonal status of female offspring from gestational stressed mothers were studied.

According to the results of our study, significant degenerative changes were found in ovaries of adult female offspring from gestationally stressed mothers, which manifest in disturbances of oogenesis and ovulation with an increase of estradiol level in the blood and body weight compared to the control which, probably, can be explained by extraovarian conversion androgens into estrogens.

Conclusion. Mothers stress during all gestational period makes negative influence on reproductive possibilities of their adult female offspring.

References

Hozhenko AI, Hryshko YUM. Aktualʹni problemy suchasnoyi medytsyny 2019;19(4): 123-129. https://doi.org/10.31718/2077-1096.19.4.123.

Gevorkian A, Ippolitov D, Bocharova T. Probl Endocrine Pathol 2022;79(1): 72-77. https://doi.org/10.21856/j-PEP.2022.1.10

Mbiydzenyuy NE, Hemmings SMJ, Qulu L. Front Behav Neurosci 2022;16: 977416. https://doi.org/10.3389/fnbeh.2022.977416.

Nazaryan R, Kryvenko L, Zakut Y, et al. Pol Merkur Lekarski 2020;48(287): 327-330.

Barker DJ, Eriksson JG, Forsén T, et al. Int J Epidemiol 2002;31(6): 1235-9. https://doi.org/10.1093/ije/31.6.1235

Barker DJ. J Amer Coll Nutr 2004;23(6): 588-595. doi: 10.1080/07315724.2004.10719428

Fowden AL, Valenzuela OA, Vaughan OR. Domest Anim Endocrinol 2016;56: 121-132.

Goldstein JM, Handa RJ, Tobet SA. Front Neuroendocrinol 2014;35(1): 140–158. https://doi.org/10.1016/j.yfrne.2013.12.001

Govoni KE, Reed SA, Zinn SA. J Anim Sci 2019;97(7): 3142-52. https://doi.org/10.1093/jas/skz157

Bräuner E, Koch V, Doherty D, et al. Comprech Psychoneuroendocrinology 2021;5: 100026. https://doi.org/10.1016/j.cpnec.2020.100026.

Garcia-Vargas D, Juarez-Rojas L, Rojas Maya S. System Biol Reprod Med 2019;65(3): 223-235. https://doi.org/10.1080/19396368.2019.1567870.

Wang JJ, Yu XW, Wu RY, et al. Cell Death Dis 2018;9(5): 452. https://doi.org/10.1038/s41419-018-0492-2.

Ashworth CJ, George SO, Hogg CO, et al. Reproduction 2016;151(6): 709-17. https://doi.org/10.1530/rep-16-0097.

European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes, Strasbourg, 1986, available at: https://rm.coe.int/168007a67b

Regulations for the Ethics Committee (Bioethics), available at: hthttps://zakon.rada.gov.ua/rada/show/v1287736-12#Text

National Research Council. Guide for the Care and Use of Laboratory Animals, National Academies Press, 2011: 246 р.

Marcondes FK, Bianchi FJ, Tanno AP. Braz J Biol 2002;62(4A): 609-14. https://doi.org/10.1590/s1519-69842002000400008.

Pratt NC. J Reprod Fert 1989;87: 763-769. https://doi.org/10.1530/jrf.0.0870763

Zorrilla EP. Dev Psychobiol 1997;30(2): 141-150. https://doi.org/10.1002/(sici)1098-2302(199703)30:2<141::aid-dev5>3.0.co;2-q.

Tuck MK, Chan DW, Chia D, et al. J Proteome Res 2009;8(1): 113-117. https://doi.org/10.1021/pr800545q.

Suvarna SK, Layton CH, Bancroft JD. Bancroft’s Theory and Practice of Histological Techniques, Elsevier Limited, 2019: 557 p.

Atramentnaya LA, Utevskaya OM. Statisticheskiye sposoby v biologii, Gorlovka, 2008: 247 p.

Sergiienko LYu, Perets OV, Kartavtseva OV, Bondarenko TV. Probl Endocrine Pathol 2010;2: 87-93. https://doi.org/10.21856/j-PEP.2010.2.13

Sergiienko LYu, Perets OV, Kartavtseva OV, et al. Probl Endocrine Pathol 2010;3: 83-89. https://doi.org/10.21856/j-PEP.2010.3.13

Gohen PG. Med Hypotheses 2001;56(6): 702-708. https://doi.org/10.1054/mehy.2000.1169

Reznikov OG, Sachinskaya OV, Falyush OA, et al. Endokrinologia 2023;28(1): 21-35. https://doi.org/10.31793/1680-1466.2023.28-1.21

Downloads

PDF EN

Published

2023-12-15

How to Cite

Gevorkyan, A., Bondarenko, T., Volokhov, I., Laryanovska, Y., Sotnik, N., Bocharova, T., … Sergienko, L. (2023). THE EFFECTS OF PRENATAL STRESS ON STRUCTURAL-FUNCTIONAL CONDITION OF FEMALE REPRODUCTIVE SYSTEM IN ADULT OFFSPRING. Problems of Endocrine Pathology, 80(4), 50–55. https://doi.org/10.21856/j-PEP.2023.4.06

Download Citation

Issue

Vol. 80 No. 4 (2023): Problems of Endocrine Pathology

Section

EXPERIMENTAL STUDIES

Most read articles by the same author(s)

Krasova N. S., Kolesnikova A. O., Gorshunska M. Yu., Plohotnichenko O. O., Tyzhnenko T. V., Leshchenko Z. A., Gladkih O. I., Voropay T. I., Romanova I. P., Zalubovskaya E. I., Sergienko L. Y., Jansen E., Misiura K. V., FUNCTIONAL ROLE OF THE TP53 GENE SINGLE NUCLEOTIDE POLYMORPHISM P72R (C>G) IN PATIENTS WITH TYPE 2 DIABETES MELLITUS OF THE EAST UKRAINIAN POPULATION , Problems of Endocrine Pathology: Vol. 80 No. 1 (2023): Problems of Endocrine Pathology
Arkhypkina T. L., Bondarenko V. O., Lyubimovа L. P., Misiura K. V., BLOOD LIPID SPECTRUM, HOMOCYSTEIN, FOLIC ACID LEVELS AND GENES INVOLVED IN FOLATE METABOLISMIN WOMEN WITH POLYCYSTIC OVARY SYNDROME , Problems of Endocrine Pathology: Vol. 80 No. 4 (2023): Problems of Endocrine Pathology
Tyzhnenko T. V., Misiura K. V., Kravchun N. O., Gorshunska M. Yu., Pochernyaev A. K., Krasova N. S., Gladkih A. I., Leshchenko Zh. A., Fedorova G. V., Plohotnichenko O. O., Hromakovska O. B., Kolesnikova A. O., Jаnsen E., Karachentsev Yu. I., Poltorak V. V., INVESTIGATION OF 2548G>A LEPTINE GENE POLYMORPHIC VARIANT IMPACT ON RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS , Problems of Endocrine Pathology: Vol. 79 No. 3 (2022): Problems of Endocrine Pathology
Tyzhnenko T. V., Misiura K. V., Kravchun N. O., Gorshunska M. Yu., Pochernyaev A. K., Krasova N. S., Gladkih O. I., Leshchenko Zh. A., Fedorova G. V., Plohotnichenko O. O., Hromakovska O. V., Kolesnikova A. O., Jansen E., Karachentsev Yu. I., Poltorak V. V., THE POLYMORPHISM -308 G/A OF THE TNF GENE AND METABOLIC IMBALANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NON-ALCOHOLIC FATTY LIVER DISEASE, TAKING INTO ACCOUNT CARDIOVASCULAR COMPLICATIONS , Problems of Endocrine Pathology: Vol. 80 No. 2 (2023): Problems of Endocrine Pathology
Gorbenko N. I., Kiprych T. V., Ivanova O. V., Borikov O. Yu., Misiura K. V., Taran K. V., THE IMPACT OF HOP EXTRACT ACTIVE COMPONENTS ON METABOLIC DISTURBANCES IN ESTROGEN DEFICIENT FEMALE RATS WITH PREDIABETES , Problems of Endocrine Pathology: Vol. 81 No. 3 (2024): Problems of Endocrine Pathology
Lurin I. A., Khoroshun E. M., Seliukova N. Yu., Boyko M. O., Misiura K. V., Nehoduiko V. V., LEVELS OF TESTOSTERONE AND SOMATOTROPIC HORMONE IN MALE COMBATANTS DEPENDING ON THE VOLUME OF BODY WOUND DAMAGE , Problems of Endocrine Pathology: Vol. 81 No. 4 (2024): Problems of Endocrine Pathology
Krasova N. S., Kolesnikova A. O., Gorshunska M. Yu., Plohotnichenko O. O., Tyzhnenko T. V., Leshchenko Zh. A., Voropay T. I., Romanova I. P., Misiura K. V., INVESTIGATION OF THE SIRT1 GENE SINGLE NUCLEOTIDE POLYMORPHISM (rs7069102) IN OVERWEIGHT PATIENTS WITH TYPE 2 DIABETES MELLITUS OF THE EAST UKRAINIAN POPULATION , Problems of Endocrine Pathology: Vol. 81 No. 4 (2024): Problems of Endocrine Pathology
Minukhin A. S., Bondarenko V. O., Misiura K. V., Skornyakov E. I., Goncharova O. A., Dubovik V. M., Dubivska S. S., Shevtsov I. I., CHARACTERISTICS OF CHANGES IN BLOOD LEPTIN IN CERTAIN VARIANTS OF INFERTILITY IN MEN , Problems of Endocrine Pathology: Vol. 81 No. 1 (2024): Problems of Endocrine Pathology
Karachentsev Yu. I., Misiura K. V., Sydorova I. V., PAGES OF GREAT HISTORY (to the 95th anniversary of the founding of the Clinic in the State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine”) , Problems of Endocrine Pathology: Vol. 79 No. 4 (2022): Problems of Endocrine Pathology
Seliukova N. Yu., Misiura K. V., Kustova S. P., Boiko M. O., Korenieva Ye. M., Mykytyuk M. R., Karachentsev Yu. I., THE REPRODUCTIVE PATHOLOGIES OF MALE OFFSPRING BORN TO MOTHERS WITH FETOPLACENTAL INSUFFICIENCY: HORMONE DEPENDENT MECHANISMS OF DEVELOPING AND PROFYLAXIS , Problems of Endocrine Pathology: Vol. 79 No. 2 (2022): Problems of Endocrine Pathology

1 2 > >>

THE EFFECTS OF PRENATAL STRESS ON STRUCTURAL-FUNCTIONAL CONDITION OF FEMALE REPRODUCTIVE SYSTEM IN ADULT OFFSPRING

Authors

DOI:

Keywords:

Abstract

References

Downloads

Published

How to Cite

Issue

Section

Most read articles by the same author(s)

Similar Articles

issn

Make a Submission

flags

indexing

Language