SOMATOTROPNE INSUFFICIENCY: PREDICTING THE EFFECTIVENESS OF RECOMBINANT GROWTH HORMONE THERAPY (LITERATURE REVIEW AND OWN DATA)

Authors

  • Bolshova O. V. SI "Institute of Endocrinology and Metabolism. VP Komisarenko National Academy of Medical Sciences of Ukraine ", Kyiv
  • Lukashuk I. V. SI "Institute of Endocrinology and Metabolism. VP Komisarenko National Academy of Medical Sciences of Ukraine ", Kyiv

DOI:

https://doi.org/10.21856/j-PEP.2011.3.11

Keywords:

short stature in children, growth hormone deficiency, Shereshevsky-Turner syndrome

Abstract

The aim of the review was to analyze the literature data on the use of predictive growth models, to study the limitations, shortcomings and to determine approaches to overcome them when creating a predictive table of the effectiveness of RECOMBINANT growth hormone therapy based on the results. examination of children with adolescent somatotropic insufficiency.

References

Большова-Зубковская, Е. В. Патология роста и полового развития у детей и подростков [Текст] / Е. В. Большова-Зубковская, Н. Д. Тронько — К.: Саммит, 2002. — 100 с.

Дедов, И. И. Эндокринология [Текст] / И. И. Дедов, Г. А. Мельниченко. — М.: Медицина, 2000. — 632 с.

Эффективность и безопасность применения рекомбинантного гормона роста у детей с идиопатической низкорослостью [Текст] / А. Н. Шандин, Е. В. Нагаева, В. А. Петеркова [и др.] // Клинич. ендокринол. — 2010. — № 6. — С. 14–23.

Height velocity targets from the national cooperative growth study for first-year growth hormone responses in short children [Text] / B. Bakker, J. Frane, H. Anhalt [et al.] // Endocrinol. Metabol. — 2008. — Vol. 93. — P. 352–357.

Ranke, M. B. The Kabi Pharmacia International Growth Study: aetiology classification list with comments [Text] / M. B. Ranke // Acta Paediatr. Scand. — 1991. — Vol. 379. — P. 87–92.

Variation in methods of predicting adult height for children with idiopathic short stature [Text] / L. S. Topor, H. A. Feldman, H. Baucher [et al.] // Pediatrics. — 2010. — Vol. 126. — P. 938–944.

De Ridder, M. A. Prediction of adult height in growth-hormone-treated children with growth hormone deficiency [Text] / M. A. de Ridder, T. Stijnen, A. C. Hokken-Koelega // J. Clin. Endocrinol. Metabol. — 2007. — Vol. 92. — P. 925–931.

Growth hormone secretory status evaluated by growth hormone peak after two pharmacological growth hormone release stimuli did not significantly influence the two-year catch-up growth induced by growth hormone therapy in 318 prepubertal short children with idiopathic growth retardation [Text] / A. Carrascosa, L. Audí, M. FernándezCancio [et al.] // Horm. Res. Paediatr. — 2011. —

Vol. 75. — P. 106–114.

Factors influencing the one- and two-year growth response in children treated with growth hormone: analysis from an observational study[Text] / J. Ross, P. A. Lee, R. Gut [et al.] // International J. Pediatr. Endocrinol. — 2010. — Vol. 1. — P. 92–98.

Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency [Text] / M. Ranke, A. Lindberg, P. Chatelain [et al.] // J. Clin. Endocrinol. Metabol. — 1999. — Vol. 84. — P. 1174–1183.

Albertsson-Wikland, K. The effect of human growth hormone injection frequency on linear growth rate [Text] / K. Albertsson-Wikland // Acta Paediatr. Scand. — 1987. — Vol. 337. — P. 110–116.

Wit, J. M. The effect of human growth hormone therapy on skinfold thickness in growth hormone80 deficient children [Text] / J. M. Wit, M. A. van’t Hof, J. L. Van den Brande // Europ. J. Pediatr. — 1988. — Vol. 147. — P. 588–592.

A dose-response curve for human growth hormone [Text] / S. D. Frasier, G. Costin, B. M. Lippe [et al.] // J. Clin. Endocrinol. Metabol. — 1981. — № 53. — P. 1213–1217.

Albertsson-Wikland, K. Validated multivariate models predicting the growth response to GH treatment in individual short children with a broad range in GH secretion capacities [Text] / K. Albertsson-Wikland, B. Kriström, S. Rosberg [et al.] // Pediatr. Res. — 2000. — Vol. 48. — P. 475–484.

Factors predicting the response to growth hormone (GH) therapy in prepubertal children with GH deficiency [Text] / S. Blethen, P. Compton, B. Lippe [et al.] // J. Clin. Endocrinol. Metabol. — 1993. — Vol. 76. — P. 574–579.

Ranke, M. B. Growth response in prepubertal children with idiopathic growth hormone deficiency during the first two years of treatment with human growth hormone. Analysis of the Kabi pharmacia international growth study [Text] / M. B. Ranke,

O. Guilbaud // Acta Paediatr. Scand. — 1991. — Vol. 379. — P. 109–115.

Prediction of growth response in children with various growth disorders treated with growth hormone: analyses of data from the Kabi pharmacia international growth study [Text] / M. Ranke, O. Guilbaud, A. Lindberg [et al.] // Acta Paediatr. — 1993. — Vol. 391. — P. 82–88.

Predicting the growth response to growth hormone (GH) treatment in prepubertal and pubertal children with isolated GH deficiency-model validation in an observational setting (GeNeSIS) [Text] / C. Land, W. F. Blum, E. Shavrikova [et al.] // J. Pediatr. Endocrinol. Metabol. — 2007. — Vol. 20. — P. 685–693.

Validation of a mathematical model predicting the response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency [Text] / J. Vosahlo, T. Zidek, J. Lebl [et al.] //Horm. Res. — 2004. — Vol. 61. — P. 143–147.

Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database) [Text] / M. B. Ranke, A. Lindberg, C. T. Cowell [et al.] // J. Clin. Endocrinol. Metabol. — 2003. — Vol. 88. — P. 125–131.

The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose [Text] / M. B. Ranke, A. Lindberg, D. D. Martin [et al.] // J. Clin. Endocrinol. Metabol. — 2003. — Vol. 88. — P. 4748–4753.

Increased response, but lower responsiveness, to growth hormone (GH) in very young children (aged 0–3 years) with idiopathic GH deficiency: analysis of data from KIGS [Text] / M. B. Ranke, A. Lindberg, K. Albertsson-Wikland [et al.] // J. Clin. Endocrinol. Metabol. — 2005. — Vol. 90. — P. 1966–1971.

Prediction of the outcome of growth hormone therapy in children with idiopathic short stature. A multivariate discriminant analysis [Text] / A. Spagnoli, G. L. Spadoni, S. Cianfarani [et al.] // J. Pediatr. — 1995. — Vol. 126. — P. 905–909.

Prediction of growth response in prepubertal children treated with growth hormone for idiopathic growth hormone deficiency [Text] / H. Südfeld, K. Kiese, A. Heinecke [et al.] // Acta Paediatr. Scand. — 2000. — Vol. 89. — P. 34–37.

A new and accurate prediction model for growth response to growth hormone treatment in children with growth hormone deficiency [Text] / E. Schönau, F. Westermann, F. Rauch [et al.] // Europ. J. Endocrinol. — 2001. — Vol. 144. — P. 13–20.

Ranke, M. B. Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables [Text] / M. B. Ranke, A. Lindberg // J. Clin. Endocrinol. Metabol. — 2010. — Vol. 95, (Suppl. 3). — P. 1229–1237.

The first-year growth response to growth hormone treatment predicts the long-term prepubertal growth response in children [Text] / B. Kriström, J. Dahlgren, A. Niklasson [et al.] // BMC Med. Inform. Decis. Mak. — 2009. — Vol. 9. — P. 1–10.

Prediction of adult height based on automated determination of bone age [Text] // H. Thodberg, O. G. Jenni, J. Caflisch [et al.] // J. Clin. Endocrinol. Metabol. — 2009. — № 94. — P. 4868–4874.

Pharmacological and physiological growth hormone stimulation tests to predict successful GH therapy in children [Text] / Anneke J. A., H. van Vught, Arie G. Nieuwenhuizen, Willem-Jan Gerver [et al.] // J. Pediatr. Endocrinol. Metabol. — 2009. — Vol. 22. — P. 679–694.

Central laboratory reassessment of IGF-I, IGFbinding protein-3, and GH serum concentrations measured at local treatment centers in growth-impaired children: implications for the agreement between outpatient screening and the results of somatotropic axis functional testing [Text] / B. P. Hauffa, N. Lehmann, M. Bettendorf [et al.] // Europ. J. Endocrinol. — 2007. — Vol. 157. — P. 597–603.

Lee, K. W. Individualized growth hormone therapy in children: advances beyond weight-based dosing [Text] / K.W. Lee, P. Cohen // J. Pediatr. Endocrinol. Metabol. — 2003. — Vol. 16 (Suppl. 3). — P. 625–630.

A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone [Text] / C. Dos Santos, L. Essioux, C. Teinturier [et al.] // Nat. Genet. — 2004. — Vol. 36. — P. 720–724.

The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short smallfor-gestational-age children [Text] / G. Binder, F. Baur, R. Schweizer [et al.] // J. Clin. Endocrinol. Metabol. — 2006. — Vol. 91. — P. 659–664.

Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency [Text] / A. A. Jorge, F. G. Marchisotti, L. R. Montenegro [et al.] // J. Clin. Endocrinol. Metabol. — 2006. — Vol. 91. — P. 1076–1080.

Common polymorphisms of the growth hormone (GH) receptor do not correlate with the growth response to exogenous recombinant human GH in Ghdeficient children [Text] / A. Pilotta, P. Mella, M. Filisetti [et al.] // J. Clin. Endocrinol. Metabol. — 2006. — Vol. 91. — P. 1178–1180.

Ranke, M. B. KIGS and KIMS as tools for evidencebased medicine [Text] / M. B. Ranke, J. Dowie // Horm. Res. — 1999. — Vol. 51 (Suppl. 1). — P. 83–86.

Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH [Text] / S. Blethen, J. Baptista, J. Kuntze [et al.] // J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82. — P. 418–420.

Dowie, J. What decision analysis can offer the clinical decision maker. Why outcome databases such as KIGS and KIMS are vital sources for decision analysis [Text] / J. Dowie // Horm. Res. — 1999. — Vol. 51 (Suppl. 1). — P. 73–82.

Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age [Text] / J. Dahlgren, B. Kristrom, A. Niklasson [et al.] // BMC Med. Inf. Decis. Mak. — 2007. — Vol. 7. — P. 40.

Kriström, B. Prediction of the growth response of short prepubertal children treated with growth hormone [Text] / B. Kriström, J. Karlberg, K. Albertsson-Wikland // Acta Paediatr. — 1995. — Vol. 84. — P. 51–57.

On behalf of the Swedish study group for growth hormone treatment, growth response to growth hormone (GH) treatment relates to serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in short children with various GH secretion capacities [Text] / B. Kriström, C. Jansson, S. Rosberg [et al.] // J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82. — P. 2889–2898.

Collagen markers deoxypyridinoline and hydroxylysine glycosides: pediatric reference data and use for growth prediction in growth hormone-deficient children [Text] // F. Rauch, M. Georg, A. Stabrey [et al.] // Clin. Chem. — 2002. — Vol. 48. — P. 315–322.

Serum bone alkaline phosphatase isoenzyme levels in normal children and children with growth hormone (GH) deficiency: a potential marker for bone formation and response to GH therapy [Text] / H. Tobiume, S. Kanzaki, S. Hida [et al.] // J. Clin. Endocrinol. Metabol. — 1997. — Vol. 82. — P. 2056–2061.

Hoos, M. B. Short-term effects of growth hormone on body composition as a predictor of growth [Text] / M. B. Hoos, K. R. Westerterp, W. J. Gerver // J. Clin. Endocrinol. Metabol. — 2003. — Vol. 88. — P. 2569–2572.

De Ridder, M. A. Validation and calibration of the Kabi Pharmacia International Growth Study prediction model for children with idiopathic growth hormone deficiency [Text] / M. A. de Ridder, T. Stijnen, A. C. Hokken-Koelega // J. Clin. Endocrinol. Metabol. — 2003. — Vol. 88. — P. 1223–1227.

Validation of a calibrated prediction model for response to growth hormone treatment in an independent cohort[Text] / M. A. de Ridder, T. Stijnen, S. L. Drop [et al.] // Horm. Res. — 2006. — Vol. 66. — P. 13–16

Downloads

Published

2011-09-27

How to Cite

Bolshova, O. V., & Lukashuk, I. V. (2011). SOMATOTROPNE INSUFFICIENCY: PREDICTING THE EFFECTIVENESS OF RECOMBINANT GROWTH HORMONE THERAPY (LITERATURE REVIEW AND OWN DATA). Problems of Endocrine Pathology, 37(3), 72-82. https://doi.org/10.21856/j-PEP.2011.3.11