PECULIARITIES OF URIC ACID METABOLISM IN MEN AND WOMEN WITH TYPE 2 DIABETES MELLITUS DEPENDING ON PHENOTYPES

Authors

DOI:

https://doi.org/10.21856/j-PEP.2022.1.08

Keywords:

diabetes mellitus, uric acid, metabolic phenotype, obesity, hypoxanthine-guanine-phosphoribosyltransferase

Abstract

Background. Uric acid (UA) metabolism disorders have been considered in recent years among the polymetabolic changes in type 2 diabetes mellitus and metabolic syndrome. UA dysmetabolism has been shown to be associated with pathophysiological phenotypes accompanied by general and/or visceral obesity and by a high cardiovascular and renal risk. However, hyperuricemia does not always occur, and urinary urate excretion studies may reveal hyperproduction and hyperexcretion of UA. The aim of our study was to establish the features of body composition and metabolic phenotype, including uricemia, insulinemia, serum lipid spectrum in patients with type 2 diabetes depending on gender, obesity and abdominal fat.

Materials and methods. We examined 47 type 2 diabetіс patients (25 men and 22 women), aged 30 to 82 years. Patients (men and women separately) were divided into subgroups: non-obese (BMI < 30 kg/m2) and obese (BMI > 30 kg/m2). Anthropometric and body composition parameters were determined: % of total fat and water, abdominal fat level, segmental distribution of fat and muscle mass by bioelectric impedance. Serum and urine UA levels were determined, UA clearance, fractional excretion relative to creatinine, hypoxanthine guanine phosphoribosyltransferase (HGFRT) activity, and carbohydrate metabolism parameters (fasting blood glucose, HbA1c, hydrochloride, insulin) were evaluated.

Results. In obese patients, compared with non-obese persons, at the background of higher levels of insulin and HOMA-IR, higher scores of visceral fat, total fat content, bone mass, body fat mass were recorded. The level of uricemia in both subgroups of both genders was within the gender norm, despite the increased or close to the upper limit of normal UA daily production. In the subgroup of men with the obesity phenotype, compared with non-obese persons, an increase in uricemia and triglycerides was found, which may be due to the influence of anabolic factors found in this group, which activate the processes of purine and fatty acid biosynthesis de novo. In obese women, compared with the non-obese subgroup, there was a significantly higher UA clearance and fractional urate excretion, due to which the level of uricemia is maintained within normal limits.

Conclusion. The study of uric acid metabolism and lipid spectrum in men and women with type 2 diabetes depending on the phenotype of obesity revealed a difference in the mechanisms that cause disorders of purine and lipid metabolism and the character of fat accumulation associated with changes in anabolic-catabolic balance, including insulin levels and the activity of the anabolic pathway of purine recycling.

References

Alkhalaqi A, Al-Naimi F, Qassmi R, et al. Medicine (Baltimore) 2020; 99(35): e21327. https://doi.org/10.1097/MD.0000000000021327

Chen C, Xu Y, Guo Z, et al. Lipids Health Dis 2014;13: 108. https://doi.org/10.1186/1476-511X-13-108

Dhana K, Koolhaas CM, van Rossum E, et al. PLoS ONE 2016;11(4): e0154273. https://doi.org/10.1371/journal.pone.0154273

Gu D, Ding Y, Zhao Y, et al. Lipids Health Dis 2018;17(1): 101. https://doi.org/10.1186/s12944-018-0761-1

Lee RA, Harris CA, Wang JC. Nucl Receptor Res 2018;5: 101373. https://doi.org/10.32527/2018/101373

Wildman R, Muntner P, Reynolds K, et al. Arch Intern Med 2008;168: 1617-1624. https://doi.org/10.1001/archinte.168.15.1617.

Rospleszcz S, Dermyshi D, Müller-Peltzer K, et al. Sci Rep 2020;10: 442. https://doi.org/10.1038/s41598-020-57459-z

Yu J, Sun H, Zhu J, et al. Diabetes Metab Syndr Obes 2021;14: 1367-1374. https://doi.org/10.2147/DMSO.S301363

Prybyla OV, Zіnych OV, Korpachev VV, et al. Ukr Med J 2020;3(2): 31-37. https://doi.org/10.32471/umj.1680-3051.137.182448

Rocha E, Vogel M, Stanik J, et al. Horm Res Pediatr 2018;90: 19-27. https://doi.org/10.1515/jpem.2003.16.9.1225

Sculley DG, Dawson PA, Emmerson BT, Gordon RB. Human Genetics 1992;90(3): 195-207. https://doi.org/10.1007/BF00220062.

Kondratyuk VE, Tarasenko OM. Ukr J Rheumatol 2018;4: 32-37, available at: http://nbuv.gov.ua/UJRN/Urj_2018_4_6.

Kondratyuk VE, Tarasenko OM, Natrus LV, Ponomareva IG. Ukr Ther J 2019;1: 75-84, available at: http://nbuv.gov.ua/UJRN/UTJ_2019_1_14.

Arshаvа ІF, Реtruk ОYu. Med Psyhologija 2017;12(4): 8-12, available at: http://nbuv.gov.ua/UJRN/Mpsl_2017_12_4_4.

Gong M, Wen S, Nguyen T, et al. Diabetes Metab Syndr Obes 2020;13: 943-962. https://doi.org/10.2147/DMSO.S232377

Lee S, Lacy ME, Jankowich M, et al. J Clin Transl Endocrinol 2019;19: 100210. https://doi.org/10.1016/j.jcte.2019.100210

Thottam GE, Krasnokutsky S, Pillinger MH. Curr Rheumatol Rep 2017;19(10): 60. https://doi.org/10.1007/s11926-017-0688-y

Grygiel-Górniak B, Mosor M, Marcinkowska J, et al. Mol Cell Biochem 2018;443(1-2): 111-119. https://doi.org/10.1007/s11010-017-3215-6

Vakalyuk IP, Seredyuk NM, Vatseba MO. Art Med 2019;1: 27-31, available at: http://nbuv.gov.ua/UJRN/artmed_2019_1_7.

Vatseba MO. Ach Clin Experim Med 2019;1: 34-39, available at: http://nbuv.gov.ua/UJRN/Zkem_2019_1_8.

Golovach IYu, Yegudina ED. Practitioner 2019;2: 9-27, available at: http://nbuv.gov.ua/UJRN/PraktLik_2019_8_2_4

Chernyaeva AA, Mykytyuk MR, Karachentsev YI, Kravchun NO. Int J Endocrinol 2019;4: 24-29. https://doi.org/10.22141/2224-0721.15.4.2019.174815

Rohde K, Keller M, la Cour Poulsen L, et al. Metabolism 2019;92: 37-50. https://doi.org/10.1016/j.metabol.2018.10.007

Maselko IR, Prokopchuk OV, Danchak SV. Nursing 2018;1: 30-32.

Qasim A, Turcotte M, de Souza RJ, et al. Obesity Rev 2018;19(2): 121-149. https://doi.org/10.1111/obr.v19.2

Islam S, Ferdous MZ, Islam U, et al. Int J Environ Res Public Health 2021;18: 1453. https://doi.org/10.3390/ijerph18041453.

Chung S, Kim GH. Electrolyte Blood Press 2021;19(1): 1-9. https://doi.org/10.5049/EBP.2021.19.1.1.

Yacovino LL, Aleksunes LM. J Biochem Mol Toxicol 2012;26(10): 407-421. https://doi.org/10.1002/jbt.21435.

Takiue Y, Hosoyamada M, Kimura M, Saito H. Nucleosides Nucleotides & Nucleic Acids 2011;30(2): 113-119. https://doi.org/10.1080/15257770.2010.551645

Mueller MB, Tuan RS. PM R 2011;3(6): S3-S11. https://doi.org/10.1016/j.pmrj.2011.05.009. PMID: 21703577.

Gus EI, Shahrokhi S, Jeschke MG. Burns 2020;46(1): 19. https://doi.org/10.1016/j.burns.2018.03.009.

Downloads

Published

2022-03-15

How to Cite

Прибила, О., Зінич, О., Кушнарьова , Н., Ковальчук, А., Корпачев, В., Шупрович, А., & Шишкань-Шишова, К. (2022). PECULIARITIES OF URIC ACID METABOLISM IN MEN AND WOMEN WITH TYPE 2 DIABETES MELLITUS DEPENDING ON PHENOTYPES. Problems of Endocrine Pathology, 79(1), 57-64. https://doi.org/10.21856/j-PEP.2022.1.08

Issue

Section

CLINICAL ENDOCRINOLOGY