FREQUENCY OF HYPERCALCEMIA AMONG PATIENTS HOSPITALIZED IN THE ENDOCRINOLOGY CLINIC

Abstract

The study is devoted to the study of the presence and severity of hypercalcemia in an inpatient group of patients with endocrine pathology according to the levels of total and ionized calcium and to the comparison of the ranking of each endocrine pathology depending on the severity of the increase in these indicators.

To do this, a retrospective analysis of the disease histories of patients who were in the clinic of the State University "Institute of Endocrine Pathology Problems of AMNU" for the period of 2020-2021 was carried out for various endocrine pathologies. During the specified period, among 2,958 patients examined for Ca content in blood serum, HC was detected in 549 patients, which was 18.56%. This indicator significantly exceeds the frequency of HC in the inpatient group of patients of the Messina University Clinic from Italy, which was equal to 4.74%. That is, in the presence of endocrine pathology, the frequency of HC in the inpatient group of patients increases about 4 times. It has been established that a higher degree of expressiveness of HC in terms of the level of total Ca occurs with PHPT, which is considered the main cause of HC. Thyroid cancer takes second place. When analyzing the level of ionized calcium, it was found that the distribution of pathological conditions has changed. The first place is occupied, as expected, by PHPT, and the second place is the formation of the adrenal glands, followed by diabetes. Other pathologies showed the same results. When analyzing the ranking positions occupied by endocrine pathologies according to the level of Ca and Ca++, it was established that the first (higher) degree of expressiveness of general HC occurs with PHPT, the second position is occupied by thyroid cancer, and the third place is shared by MNG and Grave disease. The fourth ranking position is occupied by diabetes mellitus and the formation of adrenal glands, the last - the fifth - hypothyroidism.

It has been established that the probability of hypercalcemia increases significantly in patients with endocrine pathology, which should be taken into account when monitoring such patients. Against the background of endocrine pathology, the ranking positions between the levels of total and ionized calcium change, therefore, in such patients, both forms of calcium must be investigated.