TYPE 2 DIABETES MELLITUS: COMPARISON OF INDICATORS OF THE EYE SURFACE CONDITION IN PATIENTS DEPENDING ON THE PRESENCE OF DIABETIC POLYNEUROPATHY

Authors

  • Ivzhenko L. І. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0009-0001-7148-8141
  • Bezditko P. A. Kharkiv National Medical University
  • Chernyaeva A. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine, https://orcid.org/0000-0002-2812-3323
  • Dorosh O. G. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-4033-282X
  • Karachentsev Yu. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-1317-6999
  • Boieva Yu. Yu. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2023.2.03

Keywords:

meibomian glands dysfunction, diabetic polyneuropathy, Dry eye disease, Schirmer’s test, meibography, Diabetes mellitus

Abstract

Background. Meibomian gland dysfunction (MGD) is a chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion. Diabetic polyneuropathy can be the reason of MGD. Purpose: to justify the need to improve the efficiency of diagnosis of the ocular surface pathology in patients with type 2 diabetes and diabetic polyneuropathy.

Materials and methods: standard ophthalmological examination, the Schirmer’s test before and 2 hours after compression the eyelids, the Norn’s test, OPI test, performance of squeezing secretions, IVAD, OSDI test, contact meibography with green filter. 72 patients with type 2 diabetes participated in the study. They were divided into 2 groups (group 1 – 36 patients without diabetic polyneuropathy, group 2 – 36 patients with diabetic polyneuropathy). Control group – 58 people without diabetes.

Results: The Schirmer’s test in patients of group 2 (5.98 ± 0.35 mm) was reduced by 2.3 times compared to the control group (13.92 ± 0.15 mm) (p<0.001). The Norn's test in patients of 2 group (4.47 ± 0.18 s) was below normal in 2,1 times less than in the control group (9.49 ± 0.16 s) (p<0.001). The OPI test score in group 2 patients was in 1,9 times lower than in the control group (p<0.001). The data of meibography in patients of 2 group corresponded to 4 degrees of severity, and the secretory capacity of the glands and the quality of secretion corresponded, on average, to 3 degrees and were significantly different from those of patients 1 group and the control groups (0 degree).

Conclusions: Patients with diabetic polyneuropathy have been shown to have more severe ocular surface changes than patients with only Diabetes without diabetic polyneuropathy manifestations.

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Published

2023-06-14

How to Cite

Ivzhenko, L., Bezditko, P., Chernyaeva, A., Dorosh, O., Karachentsev, Y., & Boieva, Y. (2023). TYPE 2 DIABETES MELLITUS: COMPARISON OF INDICATORS OF THE EYE SURFACE CONDITION IN PATIENTS DEPENDING ON THE PRESENCE OF DIABETIC POLYNEUROPATHY. Problems of Endocrine Pathology, 80(2), 22–30. https://doi.org/10.21856/j-PEP.2023.2.03

Issue

Vol. 80 No. 2 (2023): Problems of Endocrine Pathology

Section

CLINICAL ENDOCRINOLOGY

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