ACROMEGALY AND PREGNANCY
DOI:
https://doi.org/10.21856/j-PEP.2024.2.07Keywords:
functional pituitary adenoma, acromegaly, pregnancy, growth hormone, insulin-like growth factor-1, reviewAbstract
Diagnosis and treatment of acromegaly in pregnant women is a particular clinical problem, since the number of described cases is insignificant, and the current recommendations are based on approaches to the treatment of non-pregnant women, taking into account the specifics of the physiology of pregnancy. This publication aims to actualize the problem of diagnosis and treatment of functional pituitary adenomas with clinical signs of acromegaly during pregnancy.
The article presents four clinical cases of pregnancy of women with functional pituitary adenoma with clinical manifestations of acromegaly.
The problem of pregnancy in women with acromegaly is discussed: the effect of high levels of growth hormone and insulin-like growth factor-1 on the pregnant woman and the fetus, the pregnancy itself on the progression of functional pituitary adenoma and drug treatment on the mother and fetus.
Analysis of the literature and our own clinical experience indicate the need to revise the principles of clinical examination of patients with acromegaly of fertile age. Women with an active form of acromegaly should be informed by a doctor about the possibility of pregnancy, contraceptive methods, and risks to the mother and fetus in the event of pregnancy against the background of inadequate clinical and hormonal control of the disease. Antenatal clinicians should be informed about the peculiarities of the management of pregnant women with acromegaly, the criteria for diagnosing acromegaly, and assessing the state of clinical and hormonal control of the disease and indications for prescribing pathogenetic therapy.
Keywords: functional pituitary adenoma, acromegaly, pregnancy, growth hormone, insulin-like growth factor-1
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