FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review)

Yeugenia Koreneva; Volodymyr Bondarenko; Nataliia Brechka; Natalia Smolienko; Inna Belkina; Svitlana Kustova; Maryna Boiko; Yurii Karachentsev

doi:10.21856/j-PEP.2023.4.07

FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review)

Authors

Koreneva Ye. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-4570-6563
Bondarenko V. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-9254-3875
Brechka N. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine; Kharkiv Institute of Medicine and Biomedical Sciences, Kharkiv, Ukraine https://orcid.org/0000-0001-6132-9705
Smolienko N. P. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-2064-8608
Belkina I. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-0439-0969
Kustova S. P. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-0964-5318
Boiko M. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0001-5252-3418
Karachentsev Yu. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine; Kharkiv National Medical University, Kharkiv, Ukraine https://orcid.org/0000-0003-1317-6999

DOI:

https://doi.org/10.21856/j-PEP.2023.4.07

Keywords:

endocrinology, andrology, review, vitamin D, reproductive disturbances, benign prostatic hyperplasia

Abstract

In accordance with the statistical data, the spreading of benign prostatic hyperplasia (BPH) is increasing, because modern stressful lifestyle causes sex hormones disbalances and other dyshormonal conditions which lead to pathologies’ development at younger ages.

The pathogenesis of BPH is connected with disturbances of regulation in the hypothalamo-hypophyseal system and with the changes of the regulatory signals intensity which go to the reproductive organs. The central pathogenic links of this pathology’ development are: the declining of efficacy of hypothalamus functioning regulation which carries out on the basis of feedback; the changes of the pituitary gland cells sensitivity to the releasing hormones of hypothalamus and disbalance of sex hormones. In addition to gonadotropins prolactin has a significant impact on the BPH development. Its hypersecretion causes the development of hyperplastic age-related changes in prostate gland. The introduction of dopamine receptors antagonists such as sulpiride causes the increasing of prolactin concentration and declining of gonadotropins releasing. “Sulpiride model” is broadly used in the experimental endocrinology for studying prostate-active drugs and is characterized by sex hormones disbalance' and inflammation processes’ development. The development of the pathology is linked with the disturbance of testosterone synthesis in the testicles, insufficiency of prostate gland functioning and increasing of prolactin and estradiol concentrations which provoke proliferative changes. The androgens disbalance is the main cause of BHP development, therefore, the “Testosterone model” based on testosterone’ and estradiol’ slow releasing implants is broadly used for modeling of urination disturbance in rats which imitates the same condition in elderly men with benign prostatic hyperplasia.

The prostatitis, which developed under the condition of BHP, causes the disturbances of spermatogenesis during experimental modeling and in the clinical practice when spermatopathies, sexual disturbances and hypofertility are diagnosed in patients.

The traditional BHP therapeutic methods are not always effective and the new therapeutic approaches of hypofertility caused by prostate gland pathologies are developed by investigators. Thus, there are data about correlation between increased vitamin D consumption and decreasing of BHP spreading, between gland volume and cells proliferation in patients with this pathology. Vitamin D level influences the quantity and quality of ejaculate. The deficiency of vitamin D is associated with lower proportion of sex hormones in young men and choriogonin sensitivity of Leydig's cells to be diminished. It has been experimentally shown that cholecalciferol regulates steroid hormones genesis, mitigates the age-related declining of testicles activity, protects the testicles in old animals and the unchanged spermatogenesis in normal males which received vitamin D₃ can be considered to be the result of estrogens and androgens balance. The androgens receptors as well as vitamin D receptors have been found in prostate gland in health males and in those with hyperplasia. In addition to its classical function in calcium homeostasis and bones health, vitamin D inhibits tumor growth in different tissues including prostate gland. Vitamin D metabolites have been determined to be anti-inflammatory, proapoptotic and antiproliferative. D-hormone application potentiates the specific properties of prostate gland protectors, recovers reproductive capacity under the condition of experimental chronic prostatitis of inflammatory genesis as well as traumatic.

All facts listed above allow to confirm the positive role of D-hormone in the regulation of prostate gland and reproductive function in patients with BHP and recovering of fertility under the condition of this pathology.

The literature search for this review has been carried out on databases PubMed, Science Direct, Europa PMC, BMC, MedLine etc.

References

Seliukova NY, Gladkova AI, Koreneva EM, et al. Probl Endocrin Pathol 2019; 67(1): 87-94. https://doi.org/10.21856/j-PEP.2019.1.11.

Nikolaeva M, Arefieva A, Babayan A, et al. Reprod Sci 2021;28(1): 144-158. https://doi.org/10.1007/s43032-020-00253-z.

Bientinesi R, Gandi C, Vaccarella L, Sacco E. Urologia 2021;88(3): 163-174. https://doi.org/10.1177/0391560321994386.

Patel ND., Parsons JK. Indian J Urol 2014;30(2): 170–176. https://doi.org/10.4103/0970-1591.126900.

Sajdakova NO, Stus' VP, Dmytryshyn SP, et al. Urology 2018;22(4): 5-12. https://doi.org/10.26641/2307-5279.22.4.2018.152449.

Pasjechnikov SP, Klimenko Ya M, Moalm A, Melnichuk Ya. Health Man 2018;2: 59-64. https://doi.org/10.30841/2307-5090.2.2018.148683

Espinosa G, Esposito R, Kazzazi A, Djavan B. Can J Urol 2013; 20(4): 6820-6825.

Verze P, Cai T, Lorenzetti S. Nat Rev Urol 2016;13(7): 379-386. https://doi.org/10.1038/nrurol.2016.89.

Fullwood NJ, Lawlor AJ, Martin-Hirsch PL, et al. Sci Rep 2019;14;9(1): 4582. https://doi.org/10.1038/s41598-019-40820-2.

Calogero AE, Burgio G, Condorelli RA, et al. Aging Male 2019;22(1): 12-19. https://doi.org/10.1080/13685538.2018.1434772.

Lovett R, Banta M, Shkarni N, et al. Int J Clin Exp Pathol 2017;10(11): 10821-10829.

Barber TM, Kyrou I, Kaltsas G, et al. Int J Mol Sci 2021;22(15): 8217. https://doi.org/10.3390/ijms22158217.

Zhang MY, Wang XY, Zhang XH, Hou R. Physiol Behav 2022;249: 113744. https://doi.org/10.1016/j.physbeh.2022.113744.

Brechka NM. Ukrai'ns'kyj zhurnal medycyny, biologii' ta sportu 2019;4(5/21): 325-331. https://doi.org/10.26693/jmbs04.05.325

Van Coppenolle F, Slomianny C, Carpentier F, et al. Am J Physiol-Endocrinol Metab 2001;280(1): E120-E129. https://doi.org/10.1152/ajpendo.2001.280.1.E120.

Jakovljeva LV. Doklinichne vyvchennja likars'kyh zasobiv, pryznachenyh dlja likuvannja prostatytiv (metodychni rekomendacii'), Kyi'v, 2005: 35 р.

Zajchenko GV, Ravshanov TB. Probl Endokryn Patol 2019;1: 95-103. https://doi.org/10.21856/j-PEP.2019.1.12.

Gupta A, Ketchum N, Roehrborn CG, et al. Environ Health Perspect 2006;114(11): 1649-1654. https://doi.org/10.1289/ehp.8957.

Liu J, Fang T, Li M, et al. Sci Rep 2019;23;9(1): 19703. https://doi.org/10.1038/s41598-019-56145-z.

Marghani BH, Ezz MA, Ateya AI. Life Sci 2023;324: 121747. https://doi.org/10.1016/j.lfs.2023.121747.

Yaseen SM, Al-Samarai FR, Hasan HF. Int J Health Sci 2022;6(S1): 6076-6085. https://doi.org/10.53730/ijhs.v6nS1.6062.

Wegner KA, Ruetten H, Girardi NM, et al. Am J Clin Exp Urol 2021;9(1): 121-131.

Rivera del Alamo MM, Díaz-Lobo M, Busquets S, et al. Biochem Biophys Rep 2018;14: 26-34. https://doi.org/10.1016/j.bbrep.2018.03.005.

Lisovyi VM, Panasovskyi ML, Arkatov AV, Harahatyi IA. Probl Endocrine Pathol 2020;72(2): 66-73. https://doi.org/10.21856/j-PEP.2020.2.08.

Quintero-García M, Delgado-González E, Sánchez-Tusie A, et al. Free Radic Biol Med 2018;115: 298-308. https://doi.org/10.1016/j.freeradbiomed.2017.12.014.

Flores RB, Angrimani D, Rui BR, et al. Reprod Domest Anim 2017;52(2): 310-315. https://doi.org/10.1111/rda.12817.

Angrimani DS, Brito MM, Rui BR, et al. Sci Rep 2020;10(1): 1-9. https://doi.org/10.1038/s41598-020-71691-7.

Wolf K, Kayacelebi H, Urhausen C, et al. Reprod Domest Anim 2012;47(6): 243-246. https://doi.org/10.1111/rda.12083.

Cunto M, Mariani E, Guido EA, et al. Reprod. Domest. Anim 2019; 54, 815-822. https://doi.org/10.1111/rda.13437.

Carson C, Rittmaster R. Urology 2003;61: 2-7. https://doi.org/10.1016/S0090-4295(03)00045-1.

Savas M, Verit A, Ciftci H, et al. Nepal Med. Assoc 2009;48: 41–45.

Dearakhshandeh N, Mogheiseh A, Nazifi S, et al. J Vet Pharmacol Ther 2019;42: 665-672. https://doi.org/10.1111/jvp.12805.

Couteau N, Duquesne I, Frédéric P, et al. J Clin Med 2021;10(24): 5788. https://doi.org/10.3390/jcm10245788.

Wilson KM, Mucci LA. Adv Exp Med Biol 2019;1210: 1-27. https://doi.org/10.1007/978-3-030-32656-2_1.

Kusuma Duarsa GW, Sari YA, Gde Oka AA, et al. Asian J Urol 2021;8(3): 289-297. https://doi.org/10.1016/j.ajur.2020.06.001.

Shapoval ON, Shtrgol' SJu, Lar'janovskaja JuB, Karbovskyj VL. Vestnyk farmacyy 2015;2(68): 68-73.

Nikitin O, Klymenko Ja, Jasynec'kyj M, Zdorov’ja cholovika 2022;4: 24-30. https://doi.org/10.30841/2307-5090.4.2022.274434.

Zaychenko V, Ievtushenko O, Ruban О. ScienceRise: Pharm Sci 2017;1(5): 53-61. https://doi.org/10.15587/2519-4852.2017.93892.

Nikitin OD. Zdorovja Ukrai'ny. Urologija. Nefrologija. Andrologija 2019;2-3(16-17): 34-36.

Zaychenko V S, Ruban O A, Masliy JS, Gerbina NA. Ukr Biopharm J 2017;6(53): 4-8. https://doi.org/10.24959/ubphj.17.143.

Cohen JM, Fagin AP, Hariton E, et al. PLoS One 2012;7(8): e41941. https://doi.org/10.1371/journal.pone.0041941.

Nimptsch K, Platz EA, Willett WC, Giovannucci E. Clin Endocrinol 2012;77: 106-112 https://doi.org/10.1111/j.1365-2265.2012.04332.x.

Akbari Sagheb Z, Mohammadnia-Afrouzi M, Shafi H, et al. Caspian J Intern Med 2023;14(1): 94-99. https://doi.org/10.22088/cjim.14.1.94.

Ciccone IM, Costa EMF, Pariz JR, et al. Asian J Androl 2021;23(1): 52-58. https://doi.org/10.4103/aja.aja_9_20.

Nasreen K, Ishrat S, Banu J Int J Reprod Contracept Obstet Gynecol 2021;10: 1303-1309 https://doi.org/10.18203/2320-1770.ijrcog20211104.

Anagnostis P, Karras S, Goulis DG. Int J Clin Pract 2013;67(3): 225-233. https://doi.org/10.1111/ijcp.12031.

Maghsoumi-Norouzabad L, Javid AZ, Mansoori A, et al. Nutrition J 2021;20(1): 49. https://doi.org/10.1186/s12937-021-00711-7.

Jueraitetibaike K, Ding Z, Wang DD, et al. Asian J Androl 2019;21(4): 4. https://doi.org/10.4103/aja.aja_105_18.

Holt R, Juel Mortensen L, Harpelunde Poulsen K, et al. J Steroid Biochem Mol Biol 2020;199: 105589. https://doi.org/10.1016/j.jsbmb.2020.105589.

Chen Y, Zhi X. Endocrinology 2020;161(4): bqaa023. https://doi.org/10.1210/endocr/bqaa023.

Smolienko NP, Chystiakova EYe, Marakhovskiy IO. Polish J Sci 2021;2(45):25-27.

Karim DH, Mohammed SM, Azeez HA. Zanco J Pure Appl Sci 2021;33(1): 55-67. https://doi.org/10.21271/ZJPAS.33.1.7.

Chekman IS, Gorchakova NO, Berezhnyj VV. Sovremennaya pediatriya 2017;2(82): 28-36. https://doi.org/10.15574/SP.2017.82.28.

Mazur IP, Novoshyc'kyj VJe. Sovremennaja stomatologyja 2014;1: 40-45.

Zhang W, Zheng X, Wang Y, Xiao H. Urology 2016;97: 212-218. https://doi.org/10.1016/j.urology.2016.03.070.

Jeremy M, Gurusubramanian G, Roy VK. J Steroid Biochem Mol Biol 2019;190: 64-75. https://doi.org/10.1016/j.jsbmb.2019.03.016.

Szymczak I, Pawliczak R. Scand J Immunol 2016;83(2): 83-91. https://doi.org/10.1111/sji.12403.

Keane KN, Cruzat VF, Calton EK, et al. Reproduction 2017;153(1): R29-R42. https://doi.org/10.1530/REP-16-0386.

Giangreco AA, Dambal S, Wagner D, et al. J Steroid Biochem Mol Biol 2015;148: 156-165. https://doi.org/10.1016/j.jsbmb.2014.10.004.

Feldman D, Krishnan AV, Swami S, et al. Nat Rev Cancer 2014;14: 342-357. https://doi.org/10.1038/nrc3691.

Boisen IM, Bøllehuus Hansen L, Mortensen LJ. J Steroid Biochem Mol Biol 2017;173: 215-222. https://doi.org/10.1016/j.jsbmb.2016.09.023.

Marakhovskyi IO, Velychko NF, Korenieva YeM, et al. Probl Endocrine Pathol 2022;79(2): 80-87. https://doi.org/10.21856/j-PEP.2022.2.12.

Safwat AS, Hasanain A, Shahat A, et al. World J Urol 2019;37(7): 1347-1352. https://doi.org/10.1007/s00345-018-2536-8.

Marakhovskyi IO, Laryanovska YB, Korenieva YM, et al. Rep Morphol 2022;28(2): 25-31. https://doi.org/10.31393/morphology-journal-2022-28(2)-04.

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2023-12-15

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Koreneva, Y., Bondarenko, V., Brechka, N., Smolienko, N., Belkina, I., Kustova, S., … Karachentsev, Y. (2023). FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review). Problems of Endocrine Pathology, 80(4), 56–65. https://doi.org/10.21856/j-PEP.2023.4.07

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FERTILITY FACTORS. D-HORMONE IN PREVENTION OF REPRODUCOPATHIES CAUSED BY BENIGN PROSTATIC HYPERPLASIA (Literature review)

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