ROLE OF INDIVIDUAL MICROELEMENTS AND VITAMINS IN HASHIMOTO'S DISEASE
DOI:
https://doi.org/10.21856/j-PEP.2024.3.07Keywords:
Hashimoto's disease, micronutrients, vitamins, pathophysiology, supplementation, reviewAbstract
Introduction and objective. Hashimoto's disease is a chronic autoimmune thyroiditis. The chronic process of this disease leads to hypothyroidism. Various micronutrients and vitamins play an important role in the course of the disease and may have a significant impact on the development and treatment of Hashimoto's disease. The aim of this study is to review the literature to fully assess the impact of micronutrients on symptoms, prognosis and dynamics of change in the context of Hashimoto's disease. Articles were searched by entering keywords in PubMed databases. Scientific articles covering the period from 2016 to 2024 represent 76% of the items included in the literature. Studies from specialized research centers including meta-analyses, double-blinded randomized trials, large cross-sectional studies were considered. Studies from inexperienced centers with methodological flaws were discarded.
Abbreviated description of the state of knowledge. Current treatment of clinically overt hypothyroidism is based on the use of levothyroxine. The dose of substitution treatment is determined individually for the patient depending on the symptoms observed, TSH values and age. Currently, there are no recommendations for supplementation of microelements for the disease, which is due to the need to expand research and determine which micronutrients are worth taking to increase the quality of life of patients.
Conclusion. The number of cases of Hashimoto's disease is steadily increasing worldwide. Increasing attention is being paid to elements of the patient's diet and environment, in addition to the substitution treatment itself. The modification of a broadly defined lifestyle and the influence of environmental factors may in the near future find a place in the standard therapeutic management of patients with chronic autoimmune thyroiditis.
References
Ragusa F, Fallahi P, Elia G, et al. Best Pract Res Clin Endocrinol Metab 2019;33(6): 101367. http://doi.org/10.1016/j.beem.2019.101367
Ralli M, Angeletti D, Fiore M, et al. Autoimmun Rev 2020;19(10): 102649. http://doi.org/10.1016/j.autrev.2020.102649
Ajjan RA, Weetman AP. Horm Metab Res 2015;47(10): 702-710. http://doi.org/10.1055/s-0035-1548832
Bliddal S, Nielsen CH, Feldt-Rasmussen U. F1000Res 2017;6: 1776. http://doi.org/10.12688/f1000research.11535.1
Song RH, Yao QM, Wang B, et al. Autoimmun Rev 2019;18(10): 102368. http://doi.org/10.1016/j.autrev.2019.102368
Yao Q, Song Z, Wang B, et al. Autoimmun Rev 2019;18(6): 634-636. http://doi.org/10.1016/j.autrev.2019.01.003
Mynster Kronborg T, Frohnert Hansen J, Nielsen CH, et al. PLoS One 2016;11(4): e0154621. http://doi.org/10.1371/journal.pone.0154621
Song RH, Yu ZY, Qin Q, et al. Int J Clin Exp Pathol 2014;7(7): 4024-4031.
Wang S, Baidoo SE, Liu Y, et al. Clin Exp Immunol 2013;171(1): 63-68. http://doi.org/10.1111/j.1365-2249.2012.04670.x
Gong B, Wang C, Meng F, et al. Front Endocrinol (Lausanne) 2021;12: 774362. http://doi.org/10.3389/fendo.2021.774362
WHO Guideline: Fortification of Food-Grade Salt with Iodine for the Prevention and Control of Iodine Deficiency Disorders, Geneva, 2014: 1-54.
Krela-Kaźmierczak I, Czarnywojtek A, Skoracka K, et al. Nutrients 2021;13(2): 513. http://doi.org/10.3390/nu13020513
Luo Y, Kawashima A, Ishido Y, et al. Int J Mol Sci 2014;15(7): 12895-12912. http://doi.org/10.3390/ijms150712895
Xu C, Wu F, Mao C, et al. J Autoimmun 2016;75: 50-57. http://doi.org/10.1016/j.jaut.2016.07.008
Teti C, Panciroli M, Nazzari E, et al. Immunol Res 2021;69(2): 129-138. http://doi.org/10.1007/s12026-021-09192-6
Kieliszek M, Błażejak S. Molecules 2016;21(5): 609. http://doi.org/10.3390/molecules21050609
Duntas LH, Benvenga S. Endocrine 2015;48(3): 756-775. http://doi.org/10.1007/s12020-014-0477-6
Wang F, Li C, Li S, et al. Front Endocrinol (Lausanne) 2023;14: 1133000. http://doi.org/10.3389/fendo.2023.1133000
Xu J, Liu XL, Yang XF, et al. Biol Trace Elem Res 2011;141(1-3): 110-118. http://doi.org/10.1007/s12011-010-8728-8
Ventura M, Melo M, Carrilho F. Int J Endocrinol 2017;2017: 1297658. http://doi.org/10.1155/2017/1297658
Krysiak R, Okopien B. J Clin Endocrinol Metab 2011;96(7): 2206-2215. http://doi.org/10.1210/jc.2010-2986
Winther KH, Papini E, Attanasio R, et al. Eur Thyroid J 2020;9(2): 99-105. http://doi.org/10.1159/000504781
Rostami R, Nourooz-Zadeh S, Mohammadi A, et al. Antioxidants (Basel) 2020;9(11): 1070. http://doi.org/10.3390/antiox9111070
Wang LF, Sun RX, Li CF, Wang XH. Endokrynol Pol 2021;72(6): 666-667. http://doi.org/10.5603/EP.a2021.0074
Tian X, Li N, Su R, et al. Int J Endocrinol 2020;2020: 9210572. http://doi.org/10.1155/2020/9210572
Kryczyk-Kozioł J, Zagrodzki P, Prochownik E, et al. Int J Clin Pract 2021;75(9): e14484. http://doi.org/10.1111/ijcp.14484
Pirola I, Rotondi M, Cristiano A, et al. Endocrinol Diabetes Nutr (Engl Ed) 2020;67(1): 28-35. http://doi.org/10.1016/j.endinu.2019.03.018
Hu Y, Feng W, Chen H, et al. Clin Transl Sci 2021;14(4): 1390-1402. http://doi.org/10.1111/cts.12993
Esposito D, Rotondi M, Accardo G, et al. J Endocrinol Invest 2017;40(1): 83-89. http://doi.org/10.1007/s40618-016-0535-4
Wessels I, Maywald M, Rink L. Nutrients 2017;9(12): 1286. http://doi.org/10.3390/nu9121286
Severo JS, Morais JBS, de Freitas TEC, et al. Int J Vitam Nutr Res 2019;89(1-2): 80-88. http://doi.org/10.1024/0300-9831/a000262
Prasad AS, Bao B. Antioxidants (Basel) 2019;8(6): 164. http://doi.org/10.3390/antiox8060164
Mocchegiani E, Malavolta M, Costarelli L, et al. Curr Aging Sci 2013;6(1): 99-107. http://doi.org/10.2174/1874609811306010013
Mahmoodianfard S, Vafa M, Golgiri F, et al. J Am Coll Nutr 2015;34(5): 391-399. http://doi.org/10.1080/07315724.2014.926161
Schwalfenberg GK, Genuis SJ. Scientifica (Cairo) 2017;2017: 4179326. http://doi.org/10.1155/2017/4179326
Wang K, Wei H, Zhang W, et al. Sci Rep 2018;8(1): 9904. http://doi.org/10.1038/s41598-018-28362-5
Luo Y, Zeng H, Ye Y, et al. Environ Sci Pollut Res Int 2023;30(8): 21072-21080. http://doi.org/10.1007/s11356-022-23625-1
Aspuru K, Villa C, Bermejo F, et al. Int J Gen Med 2011;4: 741-750. http://doi.org/10.2147/IJGM.S17788
Starchl C, Scherkl M, Amrein K. Nutrients 2021;13(6): 1755. http://doi.org/10.3390/nu13061755
Rayman MP. Proc Nutr Soc 2019;78(1): 34-44. http://doi.org/10.1017/S0029665118001192
Koç Ş, Güngör K, Dokuzeylül Güngör N, et al. J Exp Clin Med 2022;39(1): 194-198.
Luo J, Wang X, Yuan L, Guo L. Front Endocrinol (Lausanne) 2021;12: 629831. http://doi.org/10.3389/fendo.2021.629831
Schmid A, Walther B. Adv Nutr 2013;4(4): 453-462. http://doi.org/10.3945/an.113.003780
Maciejewski A, Wójcicka M, Roszak M, et al. Adv Clin Exp Med 2015;24(5): 801-806. http://doi.org/10.17219/acem/29183
Fang F, Chai Y, Wei H, et al. Endocrine 2021;73(2): 447-454. http://doi.org/10.1007/s12020-021-02688-z
Xu J, Zhu XY, Sun H, et al. BMC Endocr Disord 2018;18(1): 87. http://doi.org/10.1186/s12902-018-0314-7
Cvek M, Kaličanin D, Barić A, et al. Nutrients 2021;13(8): 2793. http://doi.org/10.3390/nu13082793
Nodehi M, Ajami A, Izad M, et al. Eur J Clin Nutr 2019;73(9): 1236-1243. http://doi.org/10.1038/s41430-019-0395-z
Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, et al. Front Endocrinol (Lausanne) 2023;14: 1070592. http://doi.org/10.3389/fendo.2023.1070592
Obeid R, Heil SG, Verhoeven MMA, et al. Front Nutr 2019;6: 93. http://doi.org/10.3389/fnut.2019.00093
Aktaş HŞ. Med Princ Pract 2020;29(4): 364-370. http://doi.org/10.1159/000505094
Szczepanek-Parulska E, Hernik A, Ruchała M. Pol Arch Intern Med 2017;127(5): 352-360. http://doi.org/10.20452/pamw.3985
Kacharava T, Giorgadze E, Janjgava S, et al. Endocr Metab Immune Disord Drug Targets 2023;23(1): 86-94. http://doi.org/10.2174/1871530322666220627145635
ISSN 
ISSN 
