ЦУКРОВИЙ ДІАБЕТ 1 ТИПУ ТА ЦЕЛІАКІЯ: ОГЛЯД ЛlТЕРАТУРИ

Oksana Khyzhnyak; Myroslava Mykytyuk; Yuri Karachentsev; Olga Oleksyk; Tetiana Gavrish

doi:10.21856/j-PEP.2025.3.05

TYPE 1 DIABETES MELLITUS AND CELIAC DISEASE: A REVIEW OF LITERATURE

Authors

Khyzhnyak O. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-4541-5248
Mykytyuk M. R. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-6169-7628
Karachentsev Yu. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine; Kharkiv National Medical University, Kharkiv, Ukraine https://orcid.org/0000-0003-1317-6999
Oleksyk O. T. Uzhhorod National University, Uzhhorod, Ukraine https://orcid.org/0000-0002-9214-1120
Gavrish T. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2025.3.05

Keywords:

celiac disease, gluten, HLA, tissue-transglutaminase antibodies, type 1 diabetes mellitus, review

Abstract

Type 1 diabetes mellitus (T1DM) and gluten-sensitive celiac disease (GSD) are among the most recognized related autoimmune disorders, as they share a common genetic background that has been identified in the HLA genotype, specifically in the DQ2 and DQ8 molecules. Studies have shown that environmental factors, such as early or late cereal consumption in the first months of life or acquired viral infections, have been implicated in the risk of developing autoantigens. Celiac disease, in most cases, is asymptomatic. This article presents a review of the literature on the pathogenesis, clinical course, screening, and treatment options for type 1 diabetes mellitus in the presence of a comorbid autoimmune pathology - celiac disease.

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Published

2025-09-15

How to Cite

Khyzhnyak, O., Mykytyuk, M., Karachentsev, Y., Oleksyk, O., & Gavrish, T. (2025). TYPE 1 DIABETES MELLITUS AND CELIAC DISEASE: A REVIEW OF LITERATURE . Problems of Endocrine Pathology, 82(3), 35–42. https://doi.org/10.21856/j-PEP.2025.3.05