Pathogenetic aspects of the intermittent of the development of the polycystic ovary syndrome with prolonged cold influences in the experiment

Authors

  • Kuzmina I. U. Kharkov National Medical University, Kharkov,Ukraine
  • Zhulikova M. V. Kharkov National Medical University, Kharkov,Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2018.4.05

Keywords:

polycystic ovary syndrome, prevention, cold exposure, adipocytokines

Abstract

The aim of the research was to study the effect of intermittent cold effects (ICE) on the experimentally induced polycystic ovary syndrome (PCOS) in female rats to prevent the development of polycystic ovaries and elaboration the pathogenesis of its development. Simulation of PCOS was performed by subcutaneous injection of dehydroepiandrosterone acetate (DHEA) in rats for 25 days. A ICE was carried out by daily keeping the animals for 4 hours in a chamber in which the light regime and a temperature of + 4 °C were maintained. As a result of the experiments, it has been proved that after intracellular adaptive-compensatory reactions are activated in the ovarian tissue, which helps prevent the development of PCOS. In addition, ICE leads to an increase in the level of adipocytokines (adiponectin and leptin), which can indirectly affect the secretion of reproduction hormones and inhibit the development of cystic changes in the ovary. Stimulation of adaptive physiological reactions against the background of ICE blocks the development of signs of PCOS in rats.

References

Alieva JeA. Akusherstvo i ginekologija 2004; 4: 3-7.

Vihljaeva EM. Rukovodstvo po jendokrinnoj ginekologii, Moskva, 2009: 360-395.

Gevorkjan MA, Manuhin IB, Kushlinskij NE, Kuharkina OB. Problemy Reprodukcii 2007; 6: 38-42.

Mazurov VI, Vorohobina NV, Baranovskij AJu, Volkova EA. Bjulleten' S-Pb associacii vrachej-terapevtov 2005;2 (2): 3-17.

Grigorjan OP, Anciferov MB. Problemy Reprodukcii 2003; 3: 21-27.

Gevorkjan MA, Kushlinskij NE, Manuhin IB. Problemy Reprodukcii 2004; 6: 21-23.

Rosenfield RL, Ehrmann DA. Endocr Rev 2016; 37 (5): 467-520.

Lee MT, Anderson ES, Lee GY. Proc Natl Acad Sci USA 2016; 113 (10): 2708-2713. doi: http://doi.org/10.1073/pnas. 1523236113.

Cameron IL, Smith RE. J Cell Biol 1964; 23: 89-100.

Kuz'mina IJu, Zhulikova MV. Ukr zhurn medycyny, biologii' ta sportu 2018; 3 (3): 25-29.

Groth SW. Biol Res Nurs 2010; 12 (1): 62-72.

Deng Y, Scherer PE. Ann N Y Acad Sci 2010; 1212: E1-E19.

Mirabolghasemi G, Kamyab Z. Int J Fertil Steril 2017;11 (1): 47-55.

van der Lans AA, Hoeks J, Brans B, et al. J Clin Invest 2013; 123 (8): 3395-3403.

Fanchenko ND. Shhedrina R.N. Nejrogumoral'naja reguljacija i sostojanie reproduktivnoj sistemy v period ee aktivnogo funkcionirovanija, Moskva, 2008: 150-175.

Manuhin IB, Gevorkjan MA. Problemy Reprodukcii 2001; 6: 13-18.

Azziz R. J Clin Endocrinol Metab 2006; 91 (3): 781-785.

Patent №119800. Sposib modeljuvannja syndromu polikistoznyh jajechnykiv.

Kozyreva TV, Yakimenko MA. Fiziol Zh SSSR 1979; 65: 1598-1602

Zhang Y, Hu M, Meng F, et al. EBioMedicine 2017; 18: 157-170. doi: http://doi.org/10.1016/j.ebiom.2017.03.023.

Downloads

Published

2021-08-17

How to Cite

Kuzmina, I. U. ., & Zhulikova, M. V. . (2021). Pathogenetic aspects of the intermittent of the development of the polycystic ovary syndrome with prolonged cold influences in the experiment. Problems of Endocrine Pathology, 66(4), 44-51. https://doi.org/10.21856/j-PEP.2018.4.05