Prader-Willi syndrome, obesity, hyperphagia, diabetes mellitus, bariatric surgery


Introduction. Prader–Willi syndrome (PWS) is a genetic disease characterized by development of severe obesity in combination with a number of comorbid conditions. Known therapeutic treatments for obesity in Prader-Willi syndrome have a moderately positive effect, and surgical weight correction methods are associated with a high risk of post-operative complications.

Research objective: analyze the results of the bariatric surgical intervention by the laparoscopic distal gastric bypass with one anastomosis and the subsequent plastic correction of skin-fat flaps and excess tissues in the patient with Prader-Willi syndrome, complicated by morbid super obesity (BMI = 73 kg/m²).

Case report: One patient with a genetic disease — Prader–Willy syndrome, which was admitted to the clinic with morbid superobesity (BMI = 73 kg/m2) and its complications, is provided with a laparoscopic distal bypass with one anastomosis and a subsequent plastic correction. After the operation, the weight of the patient decreased by 80 kg, glucose and AD levels were normalized, at night the patient sleeps without the use of CPAP-machine, moving freely without dyspnea.

Discussion. Evidence for bariatric surgery in PWS patients is assumed to be a body mass index (BMI) ≥ 35 kg/m2 in combination with severe associated comorbid conditions (obstructive apnea syndrome, Pickwick syndrome, type 2 diabetes mellitus, severe form of non-alcoholic steatohepatosis, the diseases of the musculoskeletal system) or BMI ≥ 40 kg/m2 in combination with lighter associated pathologies. The search for an optimal treatment of obesity in PWS patients continues.

Conclusion. A multidisciplinary approach to the treatment of PWS patients is important, with the mandatory involvement of endocrinologists, geneticists, general practitioners and bariatric surgeons. The conduct of modern bariatric operations in combination with medicinal treatment makes it possible to achieve a steady reduction in body mass and positive medical and social rehabilitation in patients suffering from morbid obesity.


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How to Cite

Лаврик, А., Пилипенко, В., Галич, С., Згонник, А., Дмитренко, О., Дабіжа, О., & Панків, А. (2022). PRADER-WILLI SYNDROME: NEW OPPORTUNITIES IN TREATMENT OF ADOLESCENTS AND ADULTS. Problems of Endocrine Pathology, 79(1), 43-50.