CLINICAL AND IMMUNOLOGICAL MARKERS OF SLOWLY PROGRESSIVE AUTOIMMUNE DIABETES IN ADULTS (LADA)

Authors

  • Tykhonova T. M. SI "V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine", Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2015.1.08

Keywords:

Latent autoimmune diabetes of the adults, clinical manifestation, immunological markers

Abstract

262 patients were examined, among which there were 121 patients with slowly progressive autoimmune diabetes of adults (LADA), 60 type 1 diabetes mellitus (DM) patients and 81 patients with a diagnosis of type 2 DM. Based on a comparative analysis of anamnesis in patients of observation groups to the clinical features of manifestation LADA in addition to the slow nature of the manifestation it is assigned a combination of specific diabetic complaints with gradual weight loss, frequent detection of disease (64,46 %) by appealability, high blood glucose levels at diagnosis (14,12 ± 4,57 mmol/l), the possibility of episodes acetonuria without acute ketoacidotic states. It is grounded the necessity of determining at least two kinds of antibodies for the final verification of this type of diabetes. The most evidential are GAD ab and IA-2a ab. Influence of age and sex is set on frequency of presence of ICA ab and IA-2a ab. For the female patients regardless of age it is characteristically combination of positive level of GAD ab and ICA ab.

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Published

2021-06-23

How to Cite

Tykhonova, T. M. (2021). CLINICAL AND IMMUNOLOGICAL MARKERS OF SLOWLY PROGRESSIVE AUTOIMMUNE DIABETES IN ADULTS (LADA) . Problems of Endocrine Pathology, 51(1), 59-66. https://doi.org/10.21856/j-PEP.2015.1.08

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Section

CLINICAL ENDOCRINOLOGY

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