THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT

Authors

  • Karachentsev Yu. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-1317-6999
  • Gorshunska M. Yu. Kharkiv Postgraduate Medical Academy https://orcid.org/0000-0002-4402-9441
  • Atramentova L. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Kravchun N. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Khizhnyak O. O. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-4541-5248
  • Tyzhnenko T. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Grinchenko T. S. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Gladkih A. I. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Leshchenko Z. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-6141-689X
  • Shevchenko Y. A. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Pochernyaev A. K. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Romanova I. P. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine
  • Poltorak V. V. SI «V. Danilevsky Institute of Endocrine Pathology Problems of AMS of Ukraine», Kharkiv, Ukraine

DOI:

https://doi.org/10.21856/j-PEP.2010.4.01

Keywords:

single nucleotide polymorphism, adiponectin, gene, genotypes frequency, insulin resistance, type 2 diabetes mellitus

Abstract

Single nucleotide polymorphism (SNP) +45T/G gene of adiponectin (ADIPOQ) in type 2 diabetes mellitus patients and in healthy residents of Kharkiv has been taken into consideration. Frequencies of SNP +45T/G for patients (pG = 0,48; pT = 0,52) and healthy residents(pG = 0,49; pT = 0,51) do not differ significantly. The genotypes frequency in control group doesn’t correspond to HardyWeinberg equilibrium: the share of heterozygotes +45T/G is 1,8 times higher than selectively-neutral value. The type II diabetes mellitus patients have the share of heterozygotes +45T/G one third lower than in control group. The analysis has shown that heterozygotes genotype reduces the risk of type 2
diabetes mellitus in seven times (p < 0,05) in comparison with a mean value in population.

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Published

2010-12-28

How to Cite

Karachentsev, Y., Gorshunska, M., Atramentova, L. O., Kravchun, N. A., Khizhnyak, O., Tyzhnenko, T. V., … Poltorak, V. V. (2010). THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISM +45T/G OF ADIPONEKTIN GENE (ADIPOQ) IN RISK OF TYPE II DIABETES MELLITUS DEVELOPMENT. Problems of Endocrine Pathology, 34(4), 5–13. https://doi.org/10.21856/j-PEP.2010.4.01

Issue

Vol. 34 No. 4 (2010): Problems of Endocrine Pathology

Section

CLINICAL ENDOCRINOLOGY

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