THE MODERN VIEW ON THE CORRECTION OF SELENIUM DEFICIENCY FROM THE POSITION OF EVIDENCE-BASED MEDICINE (literature review and own research data)

Authors

DOI:

https://doi.org/10.21856/j-PEP.2022.4.09

Keywords:

selenium, somatic and mental diseases, depression, physical activity, correction of selenium deficiency

Abstract

Goal. To study modern data on the role of selenium (Se) in the human body, methods of assessing its content, ways of prevention and correction of selenium deficiency from the standpoint of evidence-based medicine.

Summary. The data presented in the review indicate the importance of the essential trace element Se for ensuring normal human activity. The results of the research on the supply of selenium to the population in different regions and modern approaches to the objective assessment of its content in the body are reflected. The reference rates of selenium consumption based on the determination of the concentration of selenoprotein (SePP) as the most objective marker for determining the optimal supply of Se are presented. It has been proven that a decrease or, on the contrary, an increase in the intake of dietary Se can have a negative effect on the state of health, lead to the development of chronic somatic and mental diseases including depression. Our own data on the negative impact of Se deficiency on the formation and adverse course of diffuse nontoxic goiter (DNG) in children and adolescents living in conditions of mild iodine deficiency are presented.

Ways of prevention and correction of selenium deficiency from the standpoint of evidence-based medicine and the need for individual prevention and correction of Se deficiency by prescribing dietary selenium are considered, especially in the absence of state programs that include enrichment of soils, fodder and food products with Se compounds. The expediency of including Se drugs in the complex therapy of patients with an unfavorable course of the thyroid gland, which had a positive effect on the state of the thyroid system, somato-sexual development, the state of somatic and mental health, cognitive functions and the quality of life of adolescents, has been scientifically substantiated.

The results of clinical and experimental studies are presented, which show that the inclusion of Se drugs in age-related doses in therapy can prevent the formation of metabolic syndrome and obesity, disorders of carbohydrate metabolism and thyropathies, increase the effectiveness of treatment of patients with various somatic and mental diseases, and increase physical endurance during intensive loads in athletes.

 

References

Kieliszek M. Molecules 2019;24(7): 1298. https://doi.org/10.3390/molecules24071298.

Barchielli G, Capperucci A, Tanini D. Antioxidants (Basel) 2022;11(2): 251. https://doi.org/10.3390/antiox11020251.

Duntas LH, Benvenga S. Endocrine 2015;48(3): 756-775. https://doi.org/10.1007/s12020-014-0477-6.

Jablonska E, Vinceti M. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2015;33(3): 328-368. https://doi.org/10.1080/10590501.2015.1055163.

Labunskyy VM, Hatfield DL, Gladyshev VN. Physiol Rev 2014;94: 739-777. https://doi.org/10.1152/physrev.00039.2013.

Kielczykowska M, Kocot J, Pazdzior M, Musik I. Adv Clin Exp Med 2018;27: 245-255. https://doi.org/10.17219/acem/67222.

Schomburg L. Hormones (Athens) 2020;19(1): 15-24. https://doi.org/10.1007/s42000-019-00150-4.

Valea A, Georgescu CE. Hormones (Athens) 2018;17(2): 183-196. https://doi.org/10.1007/s42000-018-0033-5.

Köhrle J. Endocrinology 2021;162(2): bqaa228. https://doi.org/10.1210/endocr/bqaa228.

Urbano T, Filippini T, Lasagni D, et al. Antioxidants (Basel) 2021;26;10(8): 1193. https://doi.org/10.3390/antiox10081193.

Tinkov AA, Skalnaya MG, Ajsuvakova OP, et al. Biol Trace Elem Res 2021;199(2): 490-499. https://doi.org/10.1007/s12011-020-02177-w.

Karachencev JuI, Goncharova OA, Podoroga EI, et al. Mіzhnar Endokrinol Zhurn 2013;5(53): 17-20.

Kravchenko VІ, Osadcіv OІ, Andrusishina ІM. Endokrinologіja 2012;17(3): 7-12.

Ning Y, Wang X, Wang S, et al. Nutrients 2015;7: 6195-6212. https://doi.org/10.3390/nu7085276.

Pavlovic Z, Miletic I, Jokic Z, et al. Biotechnol Anim Husb 2013;29: 345-352. https://doi.org/10.2298/BAH1302345P.

Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds, Washington (DC), 2000: 7. https://doi.org/10.17226/9810

Scientific Opinion on Dietary Reference Values for selenium. EFSA J 2014;12(10): 3846. https://doi.org/10.2903/j.efsa.2014.3846

Kipp AP, Strohm D, Brigelius-Flohe R, et al. J Trace Elem Med Biol 2015;32: 195-199. https://doi.org/10.1016/j.jtemb.2015.07.005

Fagan S, Owens R, Ward P, et al. Biol Trace Elem Res 2015;166: 245-259.

Constantinescu-Aruxandei D, Frîncu RM, Capră L, Oancea F. Nutrients 2018;10(10): 1466. https://doi.org/10.3390/nu10101466.

Niedzielski P, Rudnicka M, Wachelka M, et al. Food Chem 2016;190: 454-459. https://doi.org/10.1016/j.foodchem.2015.05.125.

Mahmoudi L, Mobasseri M, Ostadrahimi A, et al. Adv Biomed Res 2021;10: 33. https://doi.org/10.4103/abr.abr_252_20.

Vinceti M, Filippini T, Rothman KJ. Eur J Epidemiol 2018;33(9): 789-810. https://doi.org/10.1007/s10654-018-0422-8.

Wongdokmai R, Shantavasinkul PC, Chanprasertyothin S, et al. Diabetes Metab Syndr Obes 2021;14: 1669-1680. https://doi.org/10.2147/DMSO.S303146.

Steinbrenner H, Duntas LH, Rayman MP. Redox Biol 2022;50: 102236. https://doi.org/10.1016/j.redox.2022.102236.

Santos AC, Passos AFF, Holzbach LC, Cominetti C. Front Nutr 2021;8: 696325. https://doi.org/10.3389/fnut.2021.696325.

Panchal SK, Wanyonyi S, Brown L. Curr Hypertens Rep 2017;19(3): 10. https://doi.org/10.1007/s11906-017-0701-x.

Tinkov AA, Ajsuvakova OP, Filippini T, et al. Biomolecules 2020;10(4): 658. https://doi.org/10.3390/biom10040658.

Shi Y, Zou Y, Shen Z, et al. Int J Mol Sci 2020;21(7): 2612. https://doi.org/10.3390/ijms21072612.

Soares de Oliveira AR, Jayanne Clímaco Cruz K, Beatriz Silva Morais J, et al. Eur J Clin Invest 2021;51(9): e13538. https://doi.org/10.1111/eci.13538.

Caviglia GP, Rosso C, Armandi A, et al. Int J Mol Sci 2020;21(22): 8838. https://doi.org/10.3390/ijms21228838.

Fontenelle LC, de Paiva Sousa M, Dos Santos LR, et al. Biol Trace Elem Res 2022. https://doi.org/10.1007/s12011-022-03209-3.

Cavedon E, Manso J, Negro I, et al. Int J Endocrinol 2020;2020: 4802739. https://doi.org/10.1155/2020/4802739.

Lander RL, Enkhjargal T, Batjargal J, et al. Asia Pac J Clin Nutr 2008;17(3): 429-440.

Putro LM, Kotko DM, Goncharuk NL. Sportivna medicina, fіzichna terapіja ta ergoterapіja 2021;10: 21-25.https://doi.org/10.32652/spmed.2021.1.21-25

Goncharova OA. Probl Endokrin Patologiї 2016;1: 63-70.

Pan'kіv VІ. Klіnіchna endokrinologіja ta endokrinna hіrurgіja 2015;3(51): 79-84.

Plehova OІ, Kashkalda DA, Volkova YuV, Turchina SІ. Perіnatologіja і pedіatrіja 2015;3(63): 100-102.

Turchyna SI, Plekhova OI, Kosovtsova HV, et al. Zdorovia dytyny 2015;62: 97-101.

Matkovska T. Psykhiatriia, nevrolohiia ta medychna psykholohiia 2015;1(2): 18-22.

Plekhova OI., Kyrylova OO, Turchyna SI. Probl Endokryn Patolohii 2014;3: 47-53.

Plekhova OI, Turchyna SI, Bahatska NV, et al. Ukr zhurn dytiachoi endokrynolohii 2015;3-4: 58-66.

Turchyna SI. Mezhdunar Endokrynol Zhurn 2018;14(1): 64-71.

Li S, Sun W, Zhang D. J Alzheimers Dis 2019;72(4): 1145-1157. https://doi.org/10.3233/JAD-190263.

Samad N, Yasmin F, Manzoor N. Psychiatry Investig 2019;16(12): 948-953. https://doi.org/10.30773/pi.2019.0110.

Zborowski VA, Heck SO, Sari MHM, et al. Prog Neuropsychopharmacol Biol Psychiatry 2019;94: 109660. https://doi.org/10.1016/j.pnpbp.2019.109660.

Ghimire S, Baral BK, Feng D, et al. Nutrition 2019;62: 169-176. https://doi.org/10.1016/j.nut.2018.12.007.

Sajjadi SS, Foshati S, Haddadian-Khouzani S, Rouhani MH. Sci Rep 2022;12(1):1045. https://doi.org/10.1038/s41598-022-05078-1.

LaChance LR, Ramsey D. World J Psychiatry 2018;8(3): 97-104. https://doi.org/10.5498/wjp.v8.i3.97.

Li Z, Wang W, Xin X, et al. J Affect Disord 2018;228: 68-74. https://doi.org/10.1016/j.jad.2017.12.004.

Downloads

Published

2022-12-15

How to Cite

Турчина, С., Сотнікова-Мелешкіна, Ж., Калмикова, Ю., Калмиков, С., & Міхановська, Н. (2022). THE MODERN VIEW ON THE CORRECTION OF SELENIUM DEFICIENCY FROM THE POSITION OF EVIDENCE-BASED MEDICINE (literature review and own research data). Problems of Endocrine Pathology, 79(4), 67-73. https://doi.org/10.21856/j-PEP.2022.4.09

Most read articles by the same author(s)