THE EFFECTS OF OVERWEIGHT AND OBESITY ON THE STATE THE ORAL CAVITY IN CHILDREN AND ADOLESCENTS

Authors

DOI:

https://doi.org/10.21856/j-PEP.2025.2.09

Keywords:

overweight, obesity, children, caries, gingivitis, periodontal disease, review

Abstract

The relevance of the problem of overweight is beyond doubt. Obesity in children is not only a medical but also a social and psychological problem of our time. Our country is among the European leaders in terms of obesity prevalence. The results of scientific research show that obesity causes many diseases, including dental ones.

Dental health depends on oral hygiene, the intensity of dental caries and its complications, the impact of various orthodontic problems, the peculiarities of inflammatory processes in periodontal tissues, as well as the presence of concomitant general somatic diseases in the child's body.

Dental health often depends on what a person eats. It has been established that obese children who overconsume cakes, sweets, bakery products, and carbohydrate foods have a strong intensity of caries, as well as impaired saliva mineralization, which indicates an extensive activity of the caries process. The frequency of consumption of sugar products directly affects the intensity of caries development. It has been established that dental caries, together with overweight, is a multifactorial disease that affects the health and psychosocial development of a child.

In recent decades, it has been determined that obesity plays a significant role in the predisposition to periodontal disease and negatively affects the severity of gingivitis and periodontitis. The adverse effect of obesity on periodontal disease may be due to a state of chronic systemic inflammation. Proinflammatory cytokines such as interleukins (IL-6, TNF-α), adipokines (adiponectins and leptins) and other biologically active substances can have a direct impact on the condition of periodontal tissues.

Metabolic disorders play an important role in the pathogenesis of periodontitis. It has been found that in obesity and metabolic syndrome, the structure of the microbiocenosis of periodontal pockets is characterized by a decrease in the number of saprophytic microflora and a significant contamination with periodontopathogenic microorganisms.

Many researchers suggest that overweight patients also suffer from osteoporosis. The problem of osteoporosis is also of interest to paediatric dentists, as it directly affects the bone component of the periodontium. Many studies have shown an inverse correlation between the degree of mineralization and the severity of generalized periodontitis.

Therefore, the analysis of scientific papers confirms the presence of significant pathological changes in the oral cavity in overweight children. Interdisciplinary collaboration between paediatricians, endocrinologists and paediatric dentists will allow for a deeper investigation of the common causes and mechanisms of the pathogenesis of periodontal diseases in obese children, which will further substantiate an integrated approach to the diagnosis, treatment and prevention of major dental diseases.

Systematic literature research was carried out in the following databases: Scopus, PubMed, Web of Science, Embase, The Cochrane Library, MedLine.

References

1. Spinelli A, Buoncristiano M, Kovacs VA, et al. Obes Facts 2019;12(2): 244-258. https://doi.org/10.1159/000500436

2. Güngör NK. J Clin Res Pediatr Endocrinol 2014;6(3): 129-143. https://doi.org/10.4274/Jcrpe. 1471

3. Jebeile H, Kelly AS, O'Malley G, Baur LA. Lancet Diabetes Endocrinol 2022;10(5): 351-365. https://doi.org/10.1016/S2213-8587(22)00047-X

4. Zhang X, Liu J, Ni Y, et al. JAMA Pediatr 2024;178(8): 800-813. https://doi.org/10.1001/jamapediatrics.2024.1576

5. Brix N, Ernst A, Lauridsen LLB, et al. Int J Epidemiol 2020;49: 834-844. https://doi.org/10.1093/ije/dyaa056

6. Dereń K, Nyankovskyy S, Nyankovska O, et al. Sci Reports 2018;8(3625): 1-7. https://doi.org/10.1038/s41598–018–21773–4

7. Dereń K, Wyszyńska J, Nyankovskyy S, et al. J Clin Med 2020;9(4): 2-10. https://doi.org/10.3390/jcm9041060

8. Weihrauch-Blüher S, Wiegand S. Curr Obes Rep 2018;7(4): 254-259. https://doi.org/10.1007/s13679–018–0320–0

9. Ohnyev VA, Pomohaybo KH. Ukrayina. Zdorovʺya natsiyi 2016;4(1): 172-176.

10. Haqq AM, Kebbe M, Tan Q, et al. Child Obes 2021;17(4): 229-240. https://doi.org/10.1089/chi.2021.0003

11. Zabolotna IE, Yashchenko YUB. Ukr Zhurn Dytyachoyi Endokrynolohiyi 2017;3-4: 9-14.

12. Zabolotna IE. Klin Profilakt Medytsyna 2019;2: 36-46. https://doi.org/10.31612/2616-4868.2(8).2019.04

13. Yatsula MS, Nyanʹkovsʹkyy SL. Dytyachyy Likar 2021;4: 5-11.

14. Menezes CC, Barbirato DDS, Fogacci MF, et al. Braz Oral Res 2024;38: e031. https://doi.org/10.1590/1807-3107bor-2024.vol38.0031

15. Sheshukova OV, Veretilʹnyk AV. Visn Ukr Med Stomat Akad 2019;4(68): 77-82. https://doi.org/10.31718/2077-1096.19.4.77

16. Coll I, Vallejos D, Cuesta R, et al. J Clin Med 2024;13(23): 7283. https://doi.org/10.3390/jcm13237283

17. Dyachuk D, Yaschenko Y, Zabolotna I, Yaschenko L. Georgian Med News 2019;289: 62-67.

18. Skrypnyk M, Petrushanko T, Neporada K, et al. Folia Med (Plovdiv) 2023;65(5): 800-807. https://doi.org/10.3897/folmed.65.e98856

19. Srivastava G, Fox CK, Kelly AS, et al. Obesity (Silver Spring) 2019;27(2): 190-204. https://doi.org/10.1002/oby.22385

20. Dâmaso AR, Masquio DCL, Campos RMDS, et al. Ann N Y Acad Sci 2024;1542(1): 25-50. https://doi.org/10.1111/nyas.15251

21. Chait A, den Hartigh LJ. Front Cardiovasc Med 2020;7: 22. https://doi.org/10.3389/fcvm.2020.00022

22. Prinz N, Putri RR, Reinehr T, et al. PLoS Med 2023;20(1): e1004165. https://doi.org/10.1371/journal.pmed.1004165

23. Leary SD, Ha DH, Dudding T, Do LG. Community Dent Oral Epidemiol 2025;53(1): 50-57. https://doi.org/10.1111/cdoe.13006

24. Sheshukova OV, Kuz IO, Kostenko VO, et al. Wiad Lek 2022;75(3): 654-658. https://doi.org/10.36740/WLek202203116

25. Maksymenko AI, Sheshukova OV, Kuz IO, et al. Wiad Lek 2021;74(6): 1336-1340. https://doi.org/10.36740/WLek202106109

26. Bombin A, Yan S, Bombin S, et al. Physiol Rep 2022;10(7): e15254. https://doi.org/10.14814/phy2.15254

27. Mahboubi Z, Pakdaman A, Yazdani R, et al. Health Promot Perspect 2021;11: 271-280. https://doi.org/10.34172/hpp.2021.35

28. Pandey P, Nandkeoliar T, Tikku A, et al. J Int Soc Prev Community Dent 2021;11(3): 256-265. https://doi.org/10.4103/jispcd.JISPCD_42_21

29. Roa I, Del Sol M. Colomb Med (Cali) 2018;49(4): 280-287. https://doi.org/10.25100/cm.v49i3.3919

30. Ma T, Wu Z, Lin J, et al. Front Cell Infect Microbiol 2023;13: 1102650. https://doi.org/10.3389/fcimb.2023.1102650

31. Skrypnyk M, Petrushanko T, Neporada K, et al. Acta Fac Medic Naissensis 2022;39(3): 296-307. https://doi.org/10.5937/afmnai39-35901

32. Bezvushko EV, Kostura VL. Visn Probl Biolohiyi ta Medytsyny 2015;2: 351-355.

33. Panagiotou E, Agouropoulos A, Vadiakas G, et al. Eur Arch Paediatr Dent 2021;22(5): 861-868. https://doi.org/10.1007/s40368-021-00643-0

34. Barbosa MCF, Reis CLB, Lopes CMCF, et al. Glob Pediatr Health 2021;8: 2333794X2110012. https://doi.org/10.1177/2333794X211001237

35. Marro F, De Smedt S, Rajasekharan S, et al. Eur Arch Paediatr Dent 2021;22(1): 99-108. https://doi.org/10.1007/s40368-020-00534-w

36. Li LW, Wong HM, Sun L, et al. Adv Nutr 2015;6(6): 828-841. https://doi.org/10.3945/an. 115.010017

37. Araujo DS, Klein MI, Scudine KGO, et al. Front Pediatr 2020;8: 429. https://doi.org/10.3389/fped.2020.00429

38. Onyschenko AV, Sheshukova OV, Yeroshenko HA. Wiad Lek 2021;74(3): 423-428. https://doi.org/10.36740/WLek202103108

39. Kuz IO, Sheshukova OV, Maksymenko AI, Pysarenko OA. Stomat Bull 2022;118(1): 89-96. https://doi.org/10.35220/2078-8916-2022-43-1.16

40. Akimov OY, Kostenko VO. Ukr Biochem J 2016;88(6): 70-75. https://doi.org/10.15407/ubj88. 06.070

41. Tarasenko LM, Neporada KS, Klusha V. Bull Exp Biol Med 2002;133(4): 369-371. https://doi.org/10.1023/a:1016250121896

42. Skrypnyk M, Petrushanko T, Neporada K, et al. Dent Med Probl 2024;61(2): 197-207. https://doi.org/10.17219/dmp/157294

43. Deng Q, Wong HM, Peng S. Heliyon 2023;10(1): e23782. https://doi.org/10.1016/j.heliyon.2023.e23782

44. Yelins’ka AM, Akimov OY, Kostenko VO. Ukr Biochem J 2019;91(1): 80-85. https://doi.org/10.15407/ubj91.01.080

45. Vaziri F, Bahrololoomi Z, Savabieh Z, Sezavar K. J Indian Soc Periodontol 2022;26(1): 64-68. https://doi.org/10.4103/jisp.jisp_899_20

46. Maksymenko A, Sheshukova O, Polishchuk T, et al. Probl Endocrine Pathol 2024;81(3): 61-67. https://doi.org/10.21856/j-PEP.2024.3.08

47. Williams A, Porter J, Kingsley K, Howard KM. Pathogens 2024;13(4): 338. https://doi.org/10.3390/pathogens13040338

48. Kuz I, Akimov O, Kostenko V, et al. Probl Endocrine Pathol 2021;78(4): 34-39. https://doi.org/10.21856/j-PEP. 2021.4.05

49. Deng Q, Wong HM, Peng S. Heliyon 2023;10(1): e23782. https://doi.org/10.1016/j.heliyon.2023.e23782

50. Jia R, Zhang Y, Wang Z, et al. BMC Endocr Disord 2023;23(1): 119. https://doi.org/10.1186/s12902-023-01366-7

51. Pedersen SD. Best Pract Res Clin Endocrinol Metab 2013;27(2): 179-193. https://doi.org/10.1016/j.beem. 2013.02.004

52. Polishchuk TV, Lokhmatova NM, Sheshukova OV, et al. Wiad Lek 2021;74(1): 39-42. https://doi.org/10.36740/WLek202101107

53. Rahman B, Al-Marzooq F, Saad H, et al. Nutrients 2023;15(4): 826. https://doi.org/10.3390/nu15040826

54. Kolisnyk DA, Sylenko YUI. Ukr Stomat Alʹmanakh 2007;4: 22-24.

55. Fintini D, Cianfarani S, Cofini M, et al. Front Endocrinol (Lausanne) 2020;11: 200. https://doi.org/10.3389/fendo.2020.00200

56. Zhao P, Xu A, Leung WK. Biomolecules 2022;12(7): 865. https://doi.org/10.3390/biom12070865

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Published

2025-06-15

How to Cite

Maksymenko, A., Sheshukova, O., Onyshchenko, A., Polishchuk, T., Trufanova, V., Kazakova, K., … Pysarenko, O. (2025). THE EFFECTS OF OVERWEIGHT AND OBESITY ON THE STATE THE ORAL CAVITY IN CHILDREN AND ADOLESCENTS. Problems of Endocrine Pathology, 82(2), 68–74. https://doi.org/10.21856/j-PEP.2025.2.09

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