SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Authors

  • Tyzhnenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Atramentova L. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Karachentsev Y. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv; Kharkiv Postgraduate Medical Academy
  • Kravchun N. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Poltorak V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy, Kharkiv
  • Jаnsen E. National Institute for Public Health and the Environment, Bilthoven
  • Leshchenko Zh. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gladkih O. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Pochernyayev A. K. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Opaleiko Y. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Plohotnichenko O. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Zemlyanitcyna O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Cherniaieva A. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Chernyavskaya I. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.3.01

Keywords:

type 2 diabetes, non-alcoholic fatty liver disease, adiponectin gene, a single nucleotide polymorphism

Abstract

It was studied the single nucleotide polymorphism (SNP) in the promoter region of –11391 G > A adiponectin gene (ADIPOQ) in patients with type 2 diabetes (n = 223) and healthy inhabitants of Kharkiv (n = 51). It was established the absence of significant differences in allele frequency for SNP –11391 G > A in patients with type 2 diabetes (pG = 0.856 pA = 0.144 ), diabetes mellitus patients complicated with non-alcoholic fatty liver disease (pG = 0.850 pA = 0.150 ) and healthy individuals (pG = 0.911 pA = 0.088 ). According to the results of the study the contribution of genetic components in the propensity formation for the development of non-alcoholic fatty liver disease in patients with diabetes in SNP –11391 G > A gene ADIPOQ was not identified. The data obtained have proved promising of further research, which should be based on a study of the role of other candidate genes in the development of non-alcoholic fatty liver disease and their relationship with various metabolic parameters which may allow clarifying the role of genes in disease formation

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Published

2014-10-27

How to Cite

Tyzhnenko, T. V., Atramentova, L. O., Karachentsev, Y. I., Kravchun, N. O., Poltorak, V. V., Gorshunska, M. Y., … Chernyavskaya, I. V. (2014). SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. Problems of Endocrine Pathology, 49(3), 7–17. https://doi.org/10.21856/j-PEP.2014.3.01

Issue

Vol. 49 No. 3 (2014): Problems of Endocrine Pathology

Section

CLINICAL ENDOCRINOLOGY

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