SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Authors

  • Tyzhnenko T. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Atramentova L. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Karachentsev Y. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv; Kharkiv Postgraduate Medical Academy
  • Kravchun N. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Poltorak V. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gorshunska M. Y. Kharkiv Postgraduate Medical Academy, Kharkiv
  • Jаnsen E. National Institute for Public Health and the Environment, Bilthoven
  • Leshchenko Zh. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Gladkih O. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine
  • Krasova N. S. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Pochernyayev A. K. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Opaleiko Y. A. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Plohotnichenko O. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Zemlyanitcyna O. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Cherniaieva A. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv
  • Chernyavskaya I. V. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2014.3.01

Keywords:

type 2 diabetes, non-alcoholic fatty liver disease, adiponectin gene, a single nucleotide polymorphism

Abstract

It was studied the single nucleotide polymorphism (SNP) in the promoter region of –11391 G > A adiponectin gene (ADIPOQ) in patients with type 2 diabetes (n = 223) and healthy inhabitants of Kharkiv (n = 51). It was established the absence of significant differences in allele frequency for SNP –11391 G > A in patients with type 2 diabetes (pG = 0.856 pA = 0.144 ), diabetes mellitus patients complicated with non-alcoholic fatty liver disease (pG = 0.850 pA = 0.150 ) and healthy individuals (pG = 0.911 pA = 0.088 ). According to the results of the study the contribution of genetic components in the propensity formation for the development of non-alcoholic fatty liver disease in patients with diabetes in SNP –11391 G > A gene ADIPOQ was not identified. The data obtained have proved promising of further research, which should be based on a study of the role of other candidate genes in the development of non-alcoholic fatty liver disease and their relationship with various metabolic parameters which may allow clarifying the role of genes in disease formation

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Published

2014-10-27

How to Cite

Tyzhnenko, T. V., Atramentova, L. O., Karachentsev, Y. I., Kravchun, N. O., Poltorak, V. V., Gorshunska, M. Y., Jаnsen E., Leshchenko, Z. A., Gladkih, O. I., Krasova, N. S., Pochernyayev, A. K., Opaleiko, Y. A., Plohotnichenko, O. O., Zemlyanitcyna, O. V., Cherniaieva, A. O., & Chernyavskaya, I. V. (2014). SINGLE NUCLEOTIDE POLYMORPHISM –11391 G>A OF ADIPONECTIN GENE (ADIPOQ) IN TYPE 2 DIABETES PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE. Problems of Endocrine Pathology, 49(3), 7-17. https://doi.org/10.21856/j-PEP.2014.3.01

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Section

CLINICAL ENDOCRINOLOGY

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