PROSTATE-PROTECTIVE ACTION OF COMBINED COMPOSITION SUPPOSITORIES WITH INDOLE-3-CARBINOL AND MELOXICAM ON MODEL OF SULPIRIDE-INDUCED BENIGN PROSATE HYPERPLASIA

Authors

  • Zaychenko G. V. Bogomolets National Medical University, Kyiv
  • Ravshanov T. B. National university of pharmacy, Kharkiv

DOI:

https://doi.org/10.21856/j-PEP.2019.1.12

Keywords:

benign hyperplasia, prostate, rectal suppositories, indole-3-carbinol, 5α-reductase

Abstract

Benign prostatic hyperplasia in rats after chronic administration of sulpiride was corrected by administration (rectal suppositories) containing indole-3-carbinol and meloxicam. Established that suppositories correct the mass coefficients of the sex glands, the degree of androgenization of the organism of male rats, positively effect on concentration of fructose in seminal vesicles, activity of phosphatases and function of urinary system. Suppositories do not have a gonadotoxic effect, contribute to normalization of the hormonal function of testes with improving of spermatogenesis. A significant decrease of pathological changes in the gland at cellular level revealed: normalization of 5α-reductase activity, concentration of sex hormone receptors, as result of the specific activity of active ingredient of suppositories - indol-3-carbinol. The expressive prostate-protective action of the combined composition suppositories exceeds such a reference preparation – suppositories with pumpkin seed oil.

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Published

2019-03-04

How to Cite

Zaychenko, G. V., & Ravshanov, T. B. (2019). PROSTATE-PROTECTIVE ACTION OF COMBINED COMPOSITION SUPPOSITORIES WITH INDOLE-3-CARBINOL AND MELOXICAM ON MODEL OF SULPIRIDE-INDUCED BENIGN PROSATE HYPERPLASIA. Problems of Endocrine Pathology, 67(1), 95-103. https://doi.org/10.21856/j-PEP.2019.1.12