FUNCTIONAL STATE OF TESTICLES AND VITAMIN D LEVELS IN THE BLOOD OF YOUNG MEN WITH PROSTATE DISEASES AND INFERTILITY

Volodymyr Bondarenko; Yevheniia Korenieva; Yevheniy Skornyakov; Nataliia Brechka; Inna Belkina; Natalia Smolienko; Andriy Minuhin

doi:10.21856/j-PEP.2025.2.01

FUNCTIONAL STATE OF TESTICLES AND VITAMIN D LEVELS IN THE BLOOD OF YOUNG MEN WITH PROSTATE DISEASES AND INFERTILITY

Authors

Bondarenko V. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-9254-3875
Korenieva Ye. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0002-4570-6563
Skornyakov Ye. I. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-3733-7304
Brechka N. M. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine; Private establishment of higher education «Kharkiv institute of medicine and biomedical sciences», Kharkiv, Ukraine https://orcid.org/0000-0001-6132-9705
Belkina I. O. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-0439-0969
Smolienko N. P. SI «V. Danilevsky Institute for Endocrine Pathology Problems of the NAMS of Ukraine», Kharkiv, Ukraine https://orcid.org/0000-0003-2064-8608
Minuhin A. S. LLC «Instinct of the Sun», Kharkiv, Ukraine https://orcid.org/0000-0003-2524-7512

DOI:

https://doi.org/10.21856/j-PEP.2025.2.01

Keywords:

vitamin D, benign prostatic hyperplasia, estradiol, spermogram parameters, testosterone, chronic prostatitis

Abstract

Background. There is data indicating that the blood content of vitamin D able to influence on the level of androgenization and spermogram parameters in men. Nevertheless, how these indicators change in young men with infertility and prostatopathy depending on the presence or absence of D-hypovitaminosis is unknown.

The purpose of the work: To study the features of changes in spermatogenic and endocrine functions of the testes in men with infertility against the background of chronic prostatitis and benign prostatic hyperplasia depending on the blood level of vitamin D.

Materials and methods. The level of testosterone (T) and estradiol (E2) in the blood were analyzed by enzyme immunoassay method in 63 men aged 24-45 years with infertility and prostatopathy depending on the level of vitamin D in the blood: more or less than 30,0 ng/mL, and spermogram parameters were also determined according to WHO recommendations.

Among the examined of 32 persons had characteristics of chronic prostatitis (CP) and 31 patients had benign prostatic hyperplasia (BPH). Similarly, the hormonal status and spermogram parameters were analyzed in 27 practically healthy men of the same age, who made up the control group.

The material was statistically processed by calculating the arithmetic average indica-tors and its deviations (X̅±Sx̅), χ2 values and Pearson correlation coefficients.

Results. Infertile men with both CP and BPH in the presence of D-hypovitaminosis had significantly reduced averange levels T and T/E2 values compared to individuals whose blood vitamin D levels exceeded 30.0 ng/mL.

At the same time low blood levels of vitamin D in patients with BPH are associated with moderate androgen deficiency, when the content of T in the blood is less than 2.0 nmol/L, but exceeds 9.2 nmol/L, or the limit below which the hypogonadal androgen level is determined. (χ2 =4.68; p < 0.05).

These changes in androgenization were accompanied by a more significant decrease in the number of motile sperm forms in both groups of patients with D-hypovitaminosis. There is no correlation between the content of vitamin D and blood levels of T, as well as between the level of vitamin D and the number of sperm and their motile forms.

Conclusions. In infertile men with chronic prostatitis or signs of benign prostatic hyperplasia, under conditions of D-hypovitaminosis, there is a significant decrease in androgenization levels compared to patients in whom the content of vitamin D in the blood is normal. The presence of D-hypovitaminosis in infertile men with chronic prostatitis and benign prostatic hyperplasia significantly affects sperm motility and does not change them. In infertility in men with chronic prostatitis or benign prostatic hyperplasia, there is no correlation between the level of vitamin D and the content of testosterone in the blood, nor with sperm concentration and motility.

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Published

2025-06-15

How to Cite

Bondarenko, V., Korenieva, Y., Skornyakov, Y., Brechka, N., Belkina, I., Smolienko, N., & Minuhin, A. (2025). FUNCTIONAL STATE OF TESTICLES AND VITAMIN D LEVELS IN THE BLOOD OF YOUNG MEN WITH PROSTATE DISEASES AND INFERTILITY. Problems of Endocrine Pathology, 82(2), 7–12. https://doi.org/10.21856/j-PEP.2025.2.01